СТРЕС-ІНДУКОВАНА МОДУЛЯЦІЯ ПУХЛИННОГО МІКРООТОЧЕННЯ: МЕХАНІЗМИ ТА НАСЛІДКИ ДЛЯ ПРОГРЕСУВАННЯ РАКУ
DOI:
https://doi.org/10.15407/exp-oncology.2025.02.127Ключові слова:
стрес, пухлинне мікрооточення, пухлинна прогресіяАнотація
Хронічний стрес є одним із ключових екзогенних факторів, що можуть суттєво впливати на біологію пухлинних клітин шляхом порушення регуляції пухлинного мікрооточення (ПМО), сприяючи таким чином маніфестації пухлинного процесу. Активація гіпоталамо-гіпофізарно-наднирникової осі та симпатичної нервової системи, індукована стресовими чинниками, призводить до секреції глюкокортикоїдів і катехоламінів, які сприяють де- регуляції компонентів мікрооточення, що визначають агресивність злоякісних новоутворень. У цьому огляді систематизовано сучасні уявлення щодо впливу сигналів, індукованих стресом, на імунні, стромальні, судинні та метаболічні компоненти ПМО та проаналізовано їхній внесок у формування агресивного фенотипу пухлини. Особлива увага приділяється взаємозв’язку нейрогуморального стресу, кишкового та внутрішньопухлинного мікробіому, які формують складне мережеве середовище, що підтримує прогресію пухлини. Поглиблення розуміння молекулярних взаємодій між медіаторами стресу та клітинними елементами ПМО створить підґрунтя для розробки інноваційних терапевтичних стратегій, спрямованих не лише на саму пухлину, а й на мінімізацію несприятливого впливу стресу на окремі компоненти пухлинного мікрооточення.
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