Ovarian Epithelioid Hemangioendothelioma. Case Report
DOI:
https://doi.org/10.15407/exp-oncology.2024.04.402Keywords:
epithelioid hemangioendothelioma, ovary tumor, treatmentAbstract
Epithelioid hemangioendothelioma is a rare vascular sarcoma commonly occurring in the liver, soft tissues, and organs of the chest cavity. This study provides a detailed description of the clinical presentation, diagnosis, and treatment of epithelioid hemangioendothelioma of the ovary in a 71-year-old patient. According to the pathohistological examination, a mesenchymal tumor of the ovary with epithelioid cells was diagnosed. The immunohistochemical tests confirmed the diagnosis of epithelioid hemangioendothelioma. This clinical case is of interest for clinical practitioners due to the rare location of the tumor in female reproductive organs, which has not been previously documented in the medical literature.
References
Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Can- cer. 1982;50(5):970-981. https://doi.org/10.1002/1097-0142(19820901)50:5<970::aid-cncr2820500527>3.0.co; 2-z
Wang ZB, Yuan J, Chen W, Wei LX. Transcription factor ERG is a specific and sensitive diagnostic marker for hepatic angiosarcoma. World J Gastroenterol. 2014;20(13):3672-3679. https://doi.org/10.3748/wjg.v20.i13.3672
Lau K, Massad M, Pollak C, et al. Clinical patterns and outcome in epithelioid hemangioendothelioma with or with- out pulmonary involvement: insights from an internet registry in the study of a rare cancer. Chest. 2011;140(5):1312- 1318. https://doi.org/10.1378/chest.11-0039
Stacchiotti S, Frezza AM, Blay JY, et al. Ultra-rare sarcomas: a consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities. Cancer. 2021;127(16):2934-2942. https://doi.org/10.1002/cncr.33618
de Pinieux G, Karanian M, Le Loarer F, et al. Nationwide incidence of sarcomas and connective tissue tumors of in- termediate malignancy over four years using an expert pathology review network. PLoS ONE. 2021;16(2):e0246958. https://doi.org/10.1371/journal.pone.0246958
Nagtegaal ID, Odze RD, Klimstra D, et al. WHO Classification of Tumours Editorial Board. The 2019 WHO clas- sification of tumours of the digestive system. Histopathology. 2020;76:182-188. https://doi.org/10.1111/his.13975
Tomassen T, Versleijen-Jonkers YMH, Hillebrandt-Roeffen MHS, et al. Prognostic factors in epithelioid hemangio- endothelioma: Analysis of a nationwide molecularly/immunohistochemically confirmed cohort of 57 cases. Cancers (Basel). 2023;15(13):3304. https://doi.org/10.3390/cancers15133304
Stacchiotti S, Miah AB, Frezza AM, et al. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts. ESMO Open. 2021;6(3):100170. https://doi.org/10.1016/j.esmoop.2021.100170.
Radzikowska E, Szczepulska-Wójcik E, Chabowski M, et al. Pulmonary epithelioid haemangioendothelioma—Inter- feron 2-alpha treatment—case report. Adv Respir Med. 2008;76(4):281-285. https://doi.org/10.5603/ARM.27887
Thomas RM, Aloia TA, Truty MJ, et al. Treatment sequencing strategy for hepatic epithelioid haemangioendothe- lioma. HPB (Oxford). 2014;16:677-685. https://doi.org/ 10.1111/hpb.12202
Esma S, Marie-Christine SP, Jean G et al. Metastatic hepatic epithelioid hemangio-endothelioma: long-term response to sunitinib malate. Oncol Res Treat. 2014;37(3):124-126. https://doi.org/10.1159/000360208
Mayur V, Mohammed S, Radwan D, et al. Hepatic hemangioendothelioma: An update. World J Gastrointest Oncol.
;12(3):248-266. https://doi.org/10.4251/wjgo.v12.i3.248
Agulnik M, Yarber JL, Okuno SH, et al. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol. 2013;24(1):257-263. https://doi.org/10.1093/ annonc/mds237
Shuang M, Ryan K, Ajaybabu V P, et al. The TAZ-CAMTA1 fusion protein promotes tumorigenesis via con- nective tissue growth factor and Ras-MAPK signaling in epithelioid hemangioendothelioma. Clin Cancer Res. 2022;28(14):3116-3126. https://doi.org/10.1158/1078-0432.CCR-22-0421
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