Experimental substantiation of the use of hydroxyapatite — tricalcium phosphate bioceramics for replacing bone defects after tumor removal

Authors

  • V.F. Konovalenko R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • N.K. Ternovyi R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • E.V. Tuz R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • V.V. Protsenko SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine
  • E.O. Solonitsyn SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine
  • A. Audai SI Institute of Traumatology and Orthopedics of the NAMSU, Kyiv 01601, Ukraine
  • O.V. Drobotun Kyiv City Clinical Hospital No.3, Kyiv 02125, Ukraine
  • N.V. Ulianchych Frantsevich Institute for Problems in Materials Science

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584

Keywords:

bone, HAP-TCP, implantation, reparative osteogenesis

Abstract

Summary. Background: Recently, bioactive ceramics based on hydroxyapatite (HAP) and tricalcium phosphate (TCP) have been preferred as implants in bone engineering. Aim: To study bone regeneration under conditions of filling metaphyseal defects with the original HAP-TCP composition. Materials and Methods: The experiment was carried out on inbred rats, the observation period was 2, 4, 8 weeks. Morphological studies were carried out using light and electron microscopy. Results: In the dynamics of observation at 2, 4 and 8 weeks, a gradual arrangement of osteoclasts and osteoblasts on the surface of HAP-TCP was recorded, which indicates its high biocompatibility with bone tissue. During the experiment, the processes of resorption of implants, mineralization, proliferation of cellular elements of collagen and osteogenesis (osteoblasts and osteoclasts) and the formation of mature bone tissue were recorded. Conclusions. Experimental studies of plastic bone defects proved the presence of the osteoinductive and osteointegrative effect of HAP-TCP composition, which contributes to a more dynamic uncomplicated course of reparative osteogenesis.

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Published

26.05.2023

How to Cite

Konovalenko, V., Ternovyi, N., Tuz, E., Protsenko, V., Solonitsyn, E., Audai, A., … Ulianchych, N. (2023). Experimental substantiation of the use of hydroxyapatite — tricalcium phosphate bioceramics for replacing bone defects after tumor removal. Experimental Oncology, 43(3), 237–241. https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16584

Issue

Vol. 43 No. 3 (2021): Experimental Oncology

Section

Original contributions

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