ILLUSTRATIVE CASE OF CAPILLARY HEMANGIOMA OF THE OPTIC NERVE
DOI:
https://doi.org/10.15407/exp-oncology.2025.02.251Keywords:
capillary hemangioma, optic nerve, optic nerve chiasm, surgical removalAbstract
Capillary hemangiomas (CH) are benign proliferative vascular neoplasms commonly present in skin and soft tissues but rarely found intracranially. We describe a case of a 14-year-old male patient with histologically proven CH of the optic nerve, who underwent surgical resection of the lesion due to progressive visual loss. Imaging studies revealed a cystic-solid formation in the suprasellar region lateralized to the right and located above the pituitary gland. This case shows that CH may originate from the optic nerve, leading to its gradual compression and causing optic neuropathy. While the correct differential diagnosis on the MRI may be difficult, surgical treatment is warranted in cases of progressive visual decline.
References
Hamlat A, Adn M, Pasqualini E, et al. Pathophysiology of capillary haemangioma growth after birth. Med Hypo- theses. 2005;64(6):1093-1096. https://doi.org/10.1016/j.mehy.2004.12.026
Leonardi-Bee J, Batta K, O’Brien C, et al. Interventions for infantile haemangiomas (strawberry birthmarks) of the skin. Cochrane Database Syst Rev. 2011;11(5):CD006545. https://doi.org/10.1002/14651858.CD006545.pub3
Eibach S, Moes G, Kim J, et al. Intracranial infantile hemangioma - rare entity and common pitfalls: A compre- hensive multidisciplinary approach from Neurosurgery, Neurooncology and Neuropathology. Clin Neuropathol. 2021;40(4):180-188. https://doi.org/10.5414/NP301349. PMID:33560215
Grabb PA. Surgical management of intracranial capillary hemangiomas in children: report of 2 cases. J Neurosurg Pediatr. 2016;17(3):310-317. https://doi.org/10.3171/2015.7.PEDS14627
Okamoto A, Nakagawa I, Matsuda R, et al. Intracranial capillary hemangioma in an elderly patient. Surg Neurol Int. 2015;6(Suppl 21):539-542. https://doi.org/10.4103/2152-7806.168066
Sasaki K, Kuge A, Shimokawa Y, et al. Intracranial parenchymal capillary hemangioma: A case report. Surg Neurol Int. 2023;14:401. https://doi.org/10.25259/SNI_695_2023
Scalise R, Bolton J, Gibbs NF. Rapidly involuting congenital hemangioma (RICH): a brief case report. Dermatol Online J. 2014;20(11):13030/qt1vv2b4mg. PMID:25419759
Jalloh I, Dean AF, O’Donovan DG, et al. Giant intracranial hemangioma in aneonate. Acta Neurochir. 2014;156(6):1151- 1154. https://doi.org/10.1007/s00701-014-2007-y
Karikari IO, Selznick LA, Cummings TJ, et al. Capillary hemangioma of the fourth ventricle in an infant. Case report and review of the literature. J Neurosurg. 2006;104(3 Suppl):188-191. https://doi.org/10.3171/ped.2006.104.3.188
Sweet C, Silbergleit R, Mehta B. Primary intraosseous hemangioma of the orbit: CT and MR appearance. Am J Neuroradiol. 1997;18:379-381. PMID:9111679
Wu L, Deng X, Yang C, et al. Intramedullary spinal capillary hemangiomas: clinical features and surgical outcomes: clinical article. J Neurosurg Spine. 2013;19(4):477-484. https://doi.org/10.3171/2013.7.SPINE1369
Al-Essa RS, Helmi HA, Alkatan HM, et al. Juxtapapillary retinal capillary hemangioma: A clinical and histopatho- logical case report. Int J Surg Case Rep. 2021;79:227-230. https://doi.org/10.1016/j.ijscr.2021.01.014
Miller NR. Primary tumors of the optic nerve and its sheath. Eye Lond Engl. 2004;18(11):1026-1037. https://doi. org/10.1038/sj.eye.6701592
Stoyukhina AS, Andzhelova DV, Yusef Y. Gemangiomy diska zritel’nogo nerva [Hemangiomas of the optic nerve head]. Vestn Oft lmol. 2022;138(2):66-78. (in Russian)
Brown GC, Shields JA. Tumors of the optic nerve head. Surv Ophthalmol. 1985;29(4):239-264. PMID:3885451
Greenberg M. Greenberg’s Handbook of Neurosurgery. 10th ed. Thieme New York; 2023.
Louis DN, Perry A, Wesseling P, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231-1251. https://doi.org/10.1093/neuonc/noab106
Tasiou A, Tzerefos C, Alleyne CHJ, et al. Arteriovenous malformations: congenital or acquired lesions? World Neu- rosurg. 2020;134:799-807. https://doi.org/10.1016/j.wneu.2019.11.001
Stellon MA, Elliott R, Taheri MR, et al. Cavernous malformation of the intracranial optic nerve with operative vid- eo and review of the literature. BMJ Case Reports CP. 2020;13:e236550. https://doi.org/10.1136/bcr-2020-236550
Voznyak O, Lytvynenko A, Maydannyk O, et al. Cavernous hemangioma of the chiasm and left optic nerve. Cureus. 2020;12(5):e8068. https://doi.org/10.7759/cureus.8068
Cavalheiro S, Campos HG, Silva da Costa MD. A case of giant fetal intracranial capillary hemangioma cured with propranolol. J Neurosurg Pediatr. 2016;17(6):711-716. https://doi.org/10.3171/2015.11.PEDS15469
Low JCM, Maratos E, Kumar A, et al. Adult parasellar capillary hemangioma with intrasellar extension. World Neurosurg. 2019;124:184-191. https://doi.org/10.1016/j.wneu.2018.12.185
Xia X, Zhang H, Gao H, et al. Nearly asymptomatic intracranial capillary hemangiomas: A case report and litera- ture review. Exp Ther Med. 2017;14(3):2007-2014. https://doi.org/10.3892/etm.2017.4780
D’Amico RS, Zanazzi G, Hargus G, et al. Intracranial intraaxial cerebral tufted angioma: case report. J Neurosurg. 2018;128(2):524–529. https://doi.org/10.3171/2016.10.JNS162207
MacLellan AD, Easton AS, Alubankudi R, et al. Documented growth of an intracranial capillary hemangioma: A case report. Neuropathology. 2024;44(1):76-82. https://doi.org/10.1111/neup.12933
Abouei Mehrizi MA, Baharvahdat H, Saghebdoust S. Recurrent posterior fossa intracranial capillary hemangioma in a pregnant woman: A case report and review of literature. Ann Med Surg (Lond). 2022;84:104913. https://doi. org/10.1016/j.amsu.2022.104913. PMID:36582875
Ishikawa T, Takeuchi K, Nagata Y, et al. Case of a pregnant woman with capillary hemangioma of the parasellar region. NMC Case Rep J. 2022;9:77-82. https://doi.org/10.2176/jns-nmc.2021-0326
Noureldine MHA, Rasras S, Safari H, et al. Spontaneous regression of multiple intracranial capillary hemangio- mas in a newborn: long-term follow-up and literature review. Childs Nerv Syst. 2021;37(10):3225-3234. https://doi. org/10.1007/s00381-021-05053-7
Sahin MC, Bozkurt OF, Sahin MM, et al. Cavernous sinus capillary hemangioma: Case report and literature review.
Brain Spine. 2023;3:101776. https://doi.org/10.1016/j.bas.2023.101776
Ribeiro L, Dunoyer C, Trinquet A, et al. Adult transverse sinus capillary hemangioma: case report and review of the literature. Neurochirurgie. 2024;70(5):101573. https://doi.org/10.1016/j.neuchi.2024.101573
Algoet M, Van Dyck-Lippens PJ, Casselman J, et al. Intracanal optic nerve cavernous hemangioma: a case report and review of the literature. World Neurosurg. 2019;126:428-433. https://doi.org/10.1016/j.wneu.2019.02.202
Naughton A, Ong AY, Hildebrand GD. Safe and effective treatment of intracranial infantile hemangiomas with beta-blockers. Pediatr Rep. 2021;13(3):347-356. https://doi.org/10.3390/pediatric13030043
Meng X, Feng X, Wan J. Endoscopic endonasal transsphenoidal approach for the removal of optochiasmatic cavernoma: case report and literature review. World Neurosurg. 2017;1053:e11-e14. https://doi.org/10.1016/j. wneu.2017.07.026
Ruparelia J, Patidar R, Gosal JS, et al. Optochiasmatic cavernomas: updated systematic review and proposal of a novel classification with surgical approaches. Neurosurg Rev. 2024;47(1):53. https://doi.org/10.1007/s10143-024- 02288-1
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Experimental Oncology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
