CASE OF THE TRANSFORMATION OF PSORIASIS INTO CUTANEOUS T-CELL LYMPHOMA

Authors

  • V. TKACH Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
  • O. ALEKSANDRUK Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
  • І. KOSTYSHYN Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
  • M. VOLOSHYNOVYCH Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
  • G. GIRNYK Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
  • S. ROMANCHUK Municipal Institution «Precarpathian Clinical Dermatological and Venereological Center of Ivano-Frankivsk Regional Council», Ivano-Frankivsk, Ukraine

DOI:

https://doi.org/10.15407/exp-oncology.2024.01.068

Keywords:

diagnosis, lymphoma, psoriasis, treatment

Abstract

Psoriasis is a long-known skin pathology, the incidence of which is constantly rising, though it is not possible to clearly establish the trend due to the differences in the research design. In recent years, the number of cases among children and adolescents has increased. Psoriasis becomes more aggressive, severe forms are more common. It can be combined with other diseases but is rarely complicated. Isolated cases of the transformation of psoriatic plaques into skin cancer have already been described in the literature. Probable causes were the long-term use of photosensitizers and phototherapy, naphthalene, and tar. However, in general, the risk of the malignant recurrence in patients with psoriasis does not increase significantly. We present a clinical observation of the transformation of psoriasis into cutaneous T-cell lymphoma in a patient with more than 37 years of psoriasis experience, where on the background of typical psoriatic rashes, fungal growths of doughy consistency appeared, which were initially misinterpreted as a warty form of psoriasis. Based on the data of additional methods of examination and the results of histological examination, the diagnosis was clarified. Specific treatment was prescribed, which proved its effectiveness. The probable causes of degeneration, in our opinion, are prolonged irritating external therapy and excessive insolation.

References

World Health Organization. Global Report on Psoriasis. 2016. https://apps.who.int/iris/handle/10665/204417. Accessed on Jan 18, 2022.

Kim HO, Kang SY, Kim JC, et al. Pediatric Psoriasis: from new insights into pathogenesis to updates on treatment. Biomedicines. 2021;9(8):940. https://doi.org/10.3390/biomedicines9080940

Tkach V, Voloshynovych M, Girnyk G, Kozak N. Clinical features and the course of psoriasis in children. Przegl Dermatol. 2020;107(5):476-480. https://doi.org/10.5114/dr.2020.101677

Yamazaki F. Psoriasis: Comorbidities. J Dermatol. 2021;48(6):732-740. https://doi.org/10.1111/1346-8138.15840

Chiesa Fuxench ZC, Shin DB, Ogdie Beatty A, Gelfand JM. The risk of cancer in patients with psoriasis: a population-based cohort study in the health improvement network. JAMA Dermatol. 2016;152(3):282-290. https://doi.org/10.1001/jamadermatol.2015.4847

Davis MS, Spencer RK, Johnson CE, et al. Risk of cutaneous T Cell lymphoma with psoriasis biologic therapies. Dermatol Ther (Heidelb). 2024;14(1):15-30. https://doi.org/10.1007/s13555-023-01074-z

Soliman SH, Ramadan WM, Elashmawy AA, et al. Dermoscopy in the diagnosis of mycosis fungoides: can it help? Dermatol Pract Concept. 2023;13(4):e2023284. https://doi.org/10.5826/dpc.1304a284

Scott J, Lai C, Coltart G, et al. Coexistence of psoriasis and cutaneous T-cell lymphoma. Clin Exp Dermatol. 2023;48(10):1155-1159. https://doi.org/10.1093/ced/llad213

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Published

31.05.2024

How to Cite

TKACH, V., ALEKSANDRUK, O., KOSTYSHYN І., VOLOSHYNOVYCH, M., GIRNYK, G., & ROMANCHUK, S. (2024). CASE OF THE TRANSFORMATION OF PSORIASIS INTO CUTANEOUS T-CELL LYMPHOMA. Experimental Oncology, 46(1), 68–71. https://doi.org/10.15407/exp-oncology.2024.01.068