PRIMARY OVARIAN SYNOVIAL SARCOMA — A CASE REPORT

Authors

  • A. Yordanov Department of Gynecologic Oncology, Medical University Pleven, Pleven 5800, Bulgaria
  • K. Janeva Department of Gynecology, Saint Marina University Hospital, Pleven 5800, Bulgaria
  • S. Mateva Department of Pathology Laboratory, Saint Marina University Hospital, Pleven 5800, Bulgaria
  • Y. Kornovski Department of Obstetrics and Gynecology, University Hospital “Saint Anna”, Medical University of Varna “Prof. Dr. Paraskev Stoyanov”, Varna 9002, Bulgaria
  • S. Kostov Department of Obstetrics and Gynecology, University Hospital “Saint Anna”, Medical University of Varna “Prof. Dr. Paraskev Stoyanov”, Varna 9002, Bulgaria
  • S. Slavchev Department of Obstetrics and Gynecology, University Hospital “Saint Anna”, Medical University of Varna “Prof. Dr. Paraskev Stoyanov”, Varna 9002, Bulgaria
  • Y. Ivanova Department of Obstetrics and Gynecology, University Hospital “Saint Anna”, Medical University of Varna “Prof. Dr. Paraskev Stoyanov”, Varna 9002, Bulgaria
  • M. Nikolova Department of Gynecology, Saint Marina University Hospital, Pleven 5800, Bulgaria

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-4.19072

Keywords:

ovary, prognosis, synovial sarcoma

Abstract

Synovial sarcoma is an aggressive soft tissue sarcoma, which most often occurs in the limbs near the joints. It accounts for 5–10% of all soft tissue sarcomas. It extremely rarely affects the pelvis. So far, only 4 cases of primary involvement of the adnexa have been described. We present a case of a 77-year-old female patient diagnosed with a rapidly growing pelvic formation, subsequently diagnosed as monophasic synovial sarcoma of the ovary. Synovial sarcoma derived from the adnexa is a rare disease that is virtually unknown. The diagnosis is complex, and there is a poor prognosis.

References

de Necochea-Campion R, Zuckerman LM, Mirshahidi HR, et al. Metastatic biomarkers in synovial sarcoma. Biomark Res 2017; 5: 4. doi: https://doi.org/10.1186/s40364-017-0083-x

Rajwanshi A, Srinivas R, Upasana G. Malignant small round cell tumors. J Cytol 2009; 26: 1–10. doi: https://doi.org/10.4103/0970-9371.54861

Rong R, Doxtader EE, Tull J, et al. Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary: a molecular genetic analysis. Int J Clin Exp Pathol 2009; 3: 217–21. PMID: 20126590; PMCID: PMC2810002

Suurmeijer AJH, de Bruijin D, Geurts van Kessel A, et al. Synovial Sarcoma. In: D.M. Fletcher Christopher, A. Bridge Julia, C.W. Hogendoorn Pancras, Mertens Fredrik (Eds.), WHO Classification of Tumours of Soft Tissue and Bone, IARC Press, Lyon, 2013, p. 213–15.

Rahman MAU, Wadi KA, Nuqaydan A, Tallab R. Primary ovarian synovial sarcoma. BMJ Case Rep 2021; 14: e244756. doi: https://doi.org/10.1136/bcr-2021-244756

Thway K, Fisher C. Synovial sarcoma: defining features and diagnostic evolution. Ann Diagn Pathol 2014; 18: 369–80. doi: https://doi.org/10.1016/j.anndiagpath.2014.09.002.

Eilber FC, Dry SM. Diagnosis and management of synovial sarcoma. J Surg Oncol 2008; 97: 314–20. doi: https://doi.org/10.1002/jso.20974

Sultan I, Rodriguez-Galindo C, Saab R, et al. Comparing children and adults with synovial sarcoma in the Surveillance, Epidemiology, and End Results program, 1983 to 2005: analysis of 1268 patients. Cancer 2009; 115: 3537–47. doi: https://doi.org/10.1002/cncr.24424

Krieg AH, Hefti F, Speth BM, et al. Synovial sarcomas usually metastasize after >5 years: a multicenter retrospective analysis with minimum follow-up of 10 years for survivors. Ann Oncol 2011; 22: 458–67. doi: https://doi.org/10.1093/annonc/mdq394

Deshmukh R, Mankin HJ, Singer S. Synovial sarcoma: the importance of size and location for survival. Clin Orthop Relat Res 2004; 419: 155–61. PMID: 15021147

Vlenterie M, Litière S, Rizzo E, et al. Outcome of chemotherapy in advanced synovial sarcoma patients: Review of 15 clinical trials from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group; setting a new landmark for studies in this entity. Eur J Cancer 2016; 58: 62–72. doi: https://doi.org/10.1016/j.ejca.2016.02.002

Amankwah EK, Conley AP, Reed DR. Epidemiology and therapies for metastatic sarcoma. Clin Epidemiol 2013; 5: 147–62. doi: https://doi.org/10.2147/CLEP.S28390

Smith CJ, Ferrier AJ, Russell P, Danieletto S. Primary synovial sarcoma of the ovary: first reported case. Pathology 2005; 37: 385–7. doi: https://doi.org/10.1080/00313020500254339

Mitsuhashi A, Nagai Y, Suzuka K, et al. Primary synovial sarcoma in fallopian tube: case report and literature review. Int J Gynecol Pathol 2007; 26: 34–7. doi: https://doi.org/10.1097/01.pgp.0000225841

Nasiri S, Hasani SS, Vakilin MR, et al. Primary ovarian synovial sarcoma: the second report. J Obstet Gynecol Cancer Res 2017; 2: e62248.doi: https://doi.org/10.5812/jogcr.62248.

Lenz J, Chvátal R, Fiala L, Kavka M. Primary synovial sarcoma of the ovary and Fallopian tube — case report and review of the literature. Ceska Gynekol 2019; 84: 212–15. PMID: 31324112

Rahman MAU, Wadi KA, Nuqaydan A, et al. Primary ovarian synovial sarcoma. BMJ Case Rep 2021; 14: e244756. doi: https://doi.org/10.1136/bcr-2021-244756

Downloads

Published

09.03.2023

How to Cite

Yordanov, A., Janeva, K., Mateva, S., Kornovski, Y., Kostov, S., Slavchev, S., … Nikolova, M. (2023). PRIMARY OVARIAN SYNOVIAL SARCOMA — A CASE REPORT. Experimental Oncology, 46(4), 334–336. https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-4.19072

Issue

Vol. 46 No. 4 (2024): Experimental Oncology

Section

Case report

License

Copyright (c) 2023 Experimental Oncology

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.