IMPACT OF TUMOR MOLECULAR PHENOTYPE ON SURVIVAL OF PATIENTS WITH GASTRIC CANCER AFTER RADICAL SURGERY

Authors

  • Yu.V. Dumanskyi R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • S.I. Kirkilevskyi Target Medical Clinic, Kyiv
  • O.M. Sulaeva CSD Medical Laboratory, Kyiv
  • V.O. Polyasnyi International Humanitarian University, Odesa
  • A.O. Mashukov KNE Odesa Regional Clinical Oncological Center, Odesa
  • L.A. Kovalevska International Humanitarian University, Odesa
  • R.R. Yarema Lviv Oncological Regional Medical and Diagnostic Center, Lviv
  • M.A. Ogorchak Lviv Oncological Regional Medical and Diagnostic Center, Lviv

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-4.18903

Keywords:

Words: gastric cancer, molecular classification, tumor biology.

Abstract

The strategy for the treatment of gastric cancer (GC), in particular the use of the extended surgical interventions in different countries varies. The different proportion of specific molecular GC subtypes in various populations frequently is not taken into account for comparing treatment outcomes. This pilot study analyzes the association of survival of GC patients after the extended combined surgical interventions depending on the molecular subtype of the tumors. An improved survival for patients with diffuse cancer types (p53, VEGFR+, HER2/neu+, Ki-67+ phenotype) was demonstrated. The authors propose their point of view on the importance of recognizing GC molecular heterogeneity.

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Published

07.03.2023

How to Cite

Dumanskyi, Y., Kirkilevskyi, S., Sulaeva, O., Polyasnyi, V., Mashukov, A., Kovalevska, L., … Ogorchak, M. (2023). IMPACT OF TUMOR MOLECULAR PHENOTYPE ON SURVIVAL OF PATIENTS WITH GASTRIC CANCER AFTER RADICAL SURGERY. Experimental Oncology, 44(4), 324–326. https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-4.18903