IMPACT OF TUMOR MOLECULAR PHENOTYPE ON SURVIVAL OF PATIENTS WITH GASTRIC CANCER AFTER RADICAL SURGERY
DOI:
https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-4.18903Keywords:
Words: gastric cancer, molecular classification, tumor biology.Abstract
The strategy for the treatment of gastric cancer (GC), in particular the use of the extended surgical interventions in different countries varies. The different proportion of specific molecular GC subtypes in various populations frequently is not taken into account for comparing treatment outcomes. This pilot study analyzes the association of survival of GC patients after the extended combined surgical interventions depending on the molecular subtype of the tumors. An improved survival for patients with diffuse cancer types (p53–, VEGFR+, HER2/neu+, Ki-67+ phenotype) was demonstrated. The authors propose their point of view on the importance of recognizing GC molecular heterogeneity.
References
Fedorenko ZP, Goulak LO, Gorokh YeL, et al. Cancer in Ukraine 2020-2021: incidence, mortality, prevalence and other relevant statistics. Bull Nat Cancer Reg Ukraine 2022: 23. Available at http://www.ncru.inf.ua/ publications/BULL_23/index_e.htm
V’yun SV. Surgical tactics of treatment of patients with gastric cancer depending of the risk of the esophago-intestinal anastomosis obstruction. Ukr J Med Biol Sport 2018; 7: 84–9 (in Ukrainian).
Lazirsky VO. Surgical tactics in treatment of locally advanced complicated gastric cancer. Ukr J Med Biol Sport 2017; 5: 82–6 (in Ukrainian).
Tarasov VA, Vinogradova MV, Klechikov VZ, et al. Surgical treatment of common forms of gastric cancer. Pract Oncol 2001; 7: 52–8 (in Russian).
Yamazaki K, Tajima Y, Makino R, et al. Tumor differentiation phenotype in gastric differentiated type tumors and its relation to tumor invasion and genetic alterations. World J Gastroenterol 2006; 12: 3803–9. doi: https://doi.org/10.3748/wjg.v12.i24.3803
Hwang JE, Hong JY, Kim JE, et al. Prognostic significance of the concomitant existence of lymphovascular and perineural invasion in locally advanced gastric cancer patients who underwent curative gastrectomy and adjuvant chemotherapy. Jap J Clin Oncol 2015; 45: 541–6. doi: https://doi.org/10.1093/jjco/hyv031
He D, Zhang YW, Zhang NN, et al. Aberrant gene promoter methylation of p16, FHIT, CRBP1, WWOX, and DLC-1 in Epstein-Barr virus-associated gastric carcinomas. Med Oncol 2015; 32: 92. doi: https://doi.org/10.1007/s12032-015-0525-y
Sanjeevaiah A, Cheedella N, Hester C, Porembka MR. Gastric cancer: recent molecular classification advances, racial disparity, and management implications. J Oncol Pract 2018; 14: 217–24. doi: https://doi.org/10.1200/JOP.17.00025
Zhou L, Huang W, Yu HF, et al. Exploring TCGA database for identification of potential prognostic genes in stomach adenocarcinoma. Cancer Cell Int 2020; 20: 264. doi: https://doi.org/10.1186/s12935-020-01351-3
Wang Q, Liu G, Hu C. Molecular classification of gastric adenocarcinoma. Gastroenterol Res 2019; 12: 275–82. doi: https://doi.org/10.14740/gr1187
Qiang Wang, Qi Xie, Yang Liu, et al. Clinical characteristics and prognostic significance of TCGA and ACRG classification in gastric cancer among the Chinese population. Mol Med Rep 2020; 22: 828–40. doi: https://doi.org/10.3892/mmr.2020.11183
Weiguo C, Rong F, Weiping Y, et al. VEGF-C expression is associated with the poor survival in gastric cancer tissue. Tumor Biol 2014; 35: 3377–83. doi: https://doi.org/10.1007/s13277-013-1445-0
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