EXPRESSION OF ALPHA-SMOOTH MUSCLE ACTIN IN ODONTOGENIC CYSTS AND TUMORS

Authors

  • Malik Ajaz Ahmad People’s Dental Academy, Bhopal 462037, India
  • Anish Ashok Gupta People’s Dental Academy, Bhopal 462037, India
  • Shubhangi Ashok Mhaske People’s College of Dental Sciences, Bhopal 462037, India
  • Swati Saawarn Bhabha College of Dental Sciences, Bhopal 462026, India
  • Sahana Ashok GSL Dental College and Hospital, Rajahmundry 533296, India
  • Dakshata Mandora Rishiraj College of Dental Sciences and Research Centre, Bhopal 462036, India
  • Megha Jain Department of Dentistry, Chhindwara Institute of Medical Sciences, Chhindwara 480001, India

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-3.18676

Keywords:

immunohistochemistry, myofibroblasts, odontogenic cysts, odontogenic tumors, α-SMA

Abstract

Background: Odontogenic cysts and tumors exhibit different degrees of aggressiveness in their biological behavior. There has been evidence that the presence of myofibroblasts (MFs) at the invasion front promotes tumor invasion. Our study is based on the fact that MFs are important in the biological behavior of odontogenic cysts and tumors. Aim: To assess immunohistochemically expression of alpha-smooth muscle actin (α-SMA) of MFs in odontogenic cysts and tumors and correlate this expression to their biological behavior. Materials and Methods: The archival tissues collected for 1.5 years were obtained from the Department of Oral Pathology & Microbiology, People’s Dental Academy, Bhopal (India). A total of 40 cases consisting of 10 cases each of odontogenic keratocysts, radicular cysts, dentigerous cysts and ameloblastomas formed the study group. An immunohistochemical analysis of α-SMA expression and localization was carried out. Results: Mean MF counts were the highest in odontogenic keratocysts which was followed by ameloblastomas, entigerous cysts and radicular cysts. Weak α-SMA-expression was found in 50% of cases, moderate in 22.5% of cases, and intense — in 10% cases. MFs were arranged in the spindle, focal, or network patterns in 35; 27.5 and 20% of cases, respectively. Conclusion: The analysis revealed that the MFs were distinctly heterogeneous in distribution and pattern of arrangement. This provided persuasive evidence that stroma of these lesions harbor MFs as reflected by α-SMA immunopositive cells.

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Published

26.05.2023

How to Cite

Ahmad, M. A., Gupta, A. A., Mhaske, S. A., Saawarn, S., Ashok, S., Mandora, D., & Jain, M. (2023). EXPRESSION OF ALPHA-SMOOTH MUSCLE ACTIN IN ODONTOGENIC CYSTS AND TUMORS. Experimental Oncology, 44(3), 249–253. https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-3.18676

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Vol. 44 No. 3 (2022): Experimental Oncology

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