Granulosa and theca cell tumor in rat’s ovary after modified Biskind operation

Authors

  • D. Shamrai Bogomolets National Medical University
  • E. Koshik Medical Laboratory CSD, Kyiv 03022, Ukraine
  • N. Melnyk Kyiv Medical University

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-4.15424

Keywords:

Biskind model, granulosa cell tumor, ovary, sex cord tumor, theca cell tumor

Abstract

Summary. Background: Earlier, we described morphological changes in rat ovaries in different terms after Biskind’s operation elucidating the factors that affect the precancerous conditions and ovarian neoplasms appearance. The aim of the research was to identify tumor nature on the 120th day after modified Biskind’s operation using immunohistochemical approach. Results: We described morphological changes in rat ovaries on the 120th day after Biskind’s operation, demonstrated development of theca-granulosa cell tumors, and differentiated between Sertoli-Leydig cell tumors and theca-granulosa cell tumors using monoclonal antibodies against Ingibin-alfa, Calretinin, Melan А. Conclusion: Modified Biskind’s model could be used to study sex-cord tumors in rat ovaries.

References

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Published

30.05.2023

How to Cite

Shamrai, D., Koshik, E., & Melnyk, N. (2023). Granulosa and theca cell tumor in rat’s ovary after modified Biskind operation. Experimental Oncology, 42(4), 306–309. https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-4.15424

Issue

Vol. 42 No. 4 (2020): Experimental Oncology

Section

Original contributions

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Copyright (c) 2023 Experimental Oncology

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