Burden of malignant melanoma in Ukraine in 2002–2013: incidence, mortality and survival
DOI:
https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-4.15334Keywords:
cancer registry, incidence, malignant melanoma, mortality, stage, survivalAbstract
Summary. Background: The malignant melanoma (MM) incidence rates were increasing and later stabilizing in many regions of the world, while in South-Eastern Europe incidence rates are uniformly increasing and mortality rates are higher. Aim: To describe burden of MM in Ukraine in terms of incidence, mortality and survival by sex, age and stage for the period 2002–2013 and compare with European countries. Materials and Methods: Database of the National Cancer Registry of Ukraine was used to extract MM incidence cases; number of MM deaths was obtained from the official mortality statistics. Age-standardised and age-specific incidence and mortality rates were calculated by sex, age groups (15–39, 40–59 and 60+); estimated annual percent of change was used to describe trends. Proportions of new cases by stage of disease and calendar period (2002–2007 vs 2008–2013) were compared as well as net survival estimates. Results: In Ukraine, MM was more common in females (age-standardised 5.3 per 100,000 in 2013; annual percent of change 3.5%) than in males (5.1 per 100,000; 4.1%); around 50% of them diagnosed in the age group 60+. The observed increase in proportion of new cases with early stage (I–II) was due to stage II cases. The slight increase in mortality rates in males or stability in females were not accompanied with increase of survival. Net MM survival was consistently lower comparing to European countries. Conclusion: More resources should be targeted to increase the capacity of healthcare in diagnostics and treatment of malignant melanoma, but also in promoting healthcare and education in Ukraine.
References
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424.
Erdmann F, Lortet-Tieulent J, Schüz J, et al. International trends in the incidence of malignant melanoma 1953-2008-are recent generations at higher or lower risk? Int J Cancer 2013; 132: 385–400.
Arnold M, Holterhues C, Hollestein LM, et al. Trends in incidence and predictions of cutaneous melanoma across Europe up to 2015. J Eur Acad Dermatology Venereol 2014; 28: 1170–8.
Barbaric J, Sekerija M, Agius D, et al. Disparities in melanoma incidence and mortality in South-Eastern Europe: Increasing incidence and divergent mortality patterns. Is progress around the corner? Eur J Cancer 2016; 55: 47–55.
Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer, Lyon, France, 2018. Available from: https://gco.iarc.fr/today. Accessed 17 June, 2019.
Gandini S, Sera F, Cattaruzza MS, et al. Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur J Cancer 2005; 41: 28–44.
Gandini S, Sera F, Cattaruzza MS, et al. Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. Eur J Cancer 2005; 41: 45–60.
Gandini S, Sera F, Cattaruzza MS, et al. Meta-analysis of risk factors for cutaneous melanoma: III. Family history, actinic damage and phenotypic factors. Eur J Cancer 2005; 41: 2040–59.
Jiang AJ, Rambhatla PV, Eide MJ. Socioeconomic and lifestyle factors and melanoma: a systematic review. Br J Dermatol 2015; 172: 885–915.
The World Bank. Country and Lending Groups. Available from: http://data.worldbank.org/about/ country-and-lending-groups. Accessed 1 May 2020.
Ukraine. The World Factbook. Available from: https://www.cia.gov/ library/publications/ the-world-factbook/ index.html. Accessed 8 Apr 2020.
Weather Atlas. Weather forecast Ukraine. Available from: https://www.weather-atlas.com/en/ukraine/. Accessed 1 May 2020.
Forman D, Bray F, Brewster D, et al. Cancer Incidence in Five Continents, Volume X. IARC, Lyon, 2014.
Bray F, Colombet M, Mery L, et al. Cancer Incidence in Five Continents, Vol. XI (electronic version). Available from: http://ci5.iarc.fr/CI5-XI/Default.aspx. Accessed 13 Apr 2020.
WHO International Statistical Classification of Diseases and Related Health Problems. Tenth Revision, vol. 2. WHO, Geneva, 1993. Available from: https://apps.who.int/ iris/handle/10665/38450.
Ryzhov A, Bray F, Ferlay J, et al. Evaluation of data quality at the National Cancer Registry of Ukraine. Cancer Epidemiol 2018; 53: 156–65.
Population of Ukraine: Databank. Available from: http://database.ukrcensus.gov.ua/Mult/Database/ Population/ databasetree_en.asp. Accessed 8 Apr 2020.
Human Mortality Database. Available from: http://www.mortality.org.Accessed 8 Apr 2020.
Hermanek P, Sobin L. UICC (International Union Against Cancer) TNM Classification of Malignant Tumors. 4th ed., 2nd rev. Springer-Verlag, Berlin, Heidelberg, New York, 1992. 220 p.
Doll R, Payne P, Waterhouse J. Cancer Incidence in Five Continents: A Technical Report. Springer-Verlag (for UICC), Berlin, 1966. 244 p.
Perme MP, Stare J, Estève J. On estimation in relative survival. Biometrics 2012; 68: 113–20.
Pavlič K, Perme MP. On comparison of net survival curves. BMC Med Res Methodol 2017; 17: 79.
R Core Team. R: A language and environment for statistical computing. Available from: https://www.r-project.org/. Accessed 1 Sep 2020.
Perme MP, Pavlic K. Nonparametric relative survival analysis with the R package relsurv. J Stat Softw 2018; 87: 1–27.
Forsea AM, del Marmol V, de Vries E, et al. Melanoma incidence and mortality in Europe: new estimates, persistent disparities. Br J Dermatol 2012; 167: 1124–30.
Sacchetto L, Zanetti R, Comber H, et al. Trends in incidence of thick, thin and in situ melanoma in Europe. Eur J Cancer 2018; 92: 108–18.
Barbarić J, Znaor A. Incidence and mortality trends of melanoma in Croatia, 1988-2008. Croat Med J 2012; 53: 135–40.
Stratigos AJ, Forsea AM, van der Leest RJT, et al. Euromelanoma: a dermatology-led European campaign against nonmelanoma skin cancer and cutaneous melanoma. Past, present and future. Br J Dermatol 2012; 167: 99–104.
Lekhan V, Rudiy V, Shevchenko M, et al. Ukraine: health system review. Health Syst Transit 2015; 17: 1–154.
Welch HG, Prorok PC, O’Malley AJ, Kramer BS. Breast-cancer tumor size, overdiagnosis, and mammography screening effectiveness. N Engl J Med 2016; 375: 1438–47.
Löffeler S, Halland A, Weedon-Fekjær H, et al. High Norwegian prostate cancer mortality: evidence of over-reporting. Scand J Urol 2018; 52: 122–8.
Gondos A, Bray F, Hakulinen T, Brenner H. Trends in cancer survival in 11 European populations from 1990 to 2009: a model-based analysis. Ann Oncol 2009; 20: 564–73.
Crocetti E, Mallone S, Robsahm TE, et al. Survival of patients with skin melanoma in Europe increases further: Results of the EUROCARE-5 study. Eur J Cancer 2015; 51: 2179–90.
Miller KD, Siegel RL, Lin CC, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin 2016; 66: 271–89.
Ryzhov A, Bray F, Ferlay J, et al. Recent cancer incidence trends in Ukraine and short-term predictions to 2022. Cancer Epidemiol 2020; 65: 101663.
Fedorenko ZP, Goulak LO, Gorokh YL, et al. Cancer in Ukraine. Available from: http://www.ncru.inf.ua/publications/. Accessed 21 Jul 2017.
Barbaric J, Laversanne M, Znaor A. Malignant melanoma incidence trends in a Mediterranean population following socioeconomic transition and war. Melanoma Res 2017; 27: 498–502.
Romaniuk P, Semigina T. Ukrainian health care system and its chances for successful transition from Soviet legacies. Global Health 2018; 14: 116.
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