NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer

Authors

  • K.A. Gaptulbarova Research Institute of Oncology, Tomsk National Research Medical Center of the Russian Academy of Science
  • M.M. Tsyganov Research Institute of Oncology, Tomsk National Research Medical Center of the Russian Academy of Science
  • A.M. Pevzner Research Institute of Oncology, Tomsk National Research Medical Center of the Russian Academy of Science
  • M.K. Ibragimova Research Institute of Oncology, Tomsk National Research Medical Center of the Russian Academy of Sciences
  • N.V. Litviakov Research Institute of Oncology, Tomsk National Research Medical Center of the Russian Academy of Sciences

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-4.15414

Keywords:

homologous recombination deficiency, marker, NF-kB1, personalized medicine

Abstract

Summary. The NF-kB1 gene belongs to the family of transcription factors that are involved in the regulation of a wide range of biological reactions. It has been established that NF-kB1 plays an important role in the regulation of immune responses, but more and more studies indicate that this gene is involved in the processes of oncogenesis and DNA repair. The product of this gene regulates the expression of genes involved in the development and progression of cancer. In recent years, numerous studies have been aimed at elucidating the functional consequences of the activation of NF-kB1, as well as its signaling mechanisms. In this regard, NF-kB1 is an interesting therapeutic target for a possible personalized approach in the treatment of cancer. This article provides an overview of modern clinical studies of the NF-kB1 gene, which acts as a predictive and prognostic marker in the treatment of cancer.

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Published

30.05.2023

How to Cite

Gaptulbarova, K., Tsyganov, M., Pevzner, A., Ibragimova, M., & Litviakov, N. (2023). NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer. Experimental Oncology, 42(4), 263–269. https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-4.15414

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