Histopathological characteristics and post-operative follow-up of patients with potentially radiogenic papillary thyroid carcinoma depending on oncocytic changes availability in the tumor cells

Authors

  • T. Bogdanova Laboratory of Morphology of Endocrine System, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine
  • L. Zurnadzhy Laboratory of Morphology of Endocrine System, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine
  • S. Masiuk Department of Dosimetry, State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv 02000, Ukraine
  • S. Burko Laboratory of Morphology of Endocrine System, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine
  • T. Degtyaryova Laboratory of Morphology of Endocrine System, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine
  • A. Kovalenko Department of Surgery of Endocrine Glands, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine
  • M. Bolgov Department of Surgery of Endocrine Glands, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine
  • S. Chernyshov Department of Surgery of Endocrine Glands, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine
  • S. Gulevatyi Department of Radiology, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine
  • G. Thomas Chornobyl Tissue Bank, Imperial College, London W6 8RF, United Kingdom
  • M. Tronko Department of Fundamental and Applied Problems of Endocrinology, State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine”, Kyiv 04114, Ukraine

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-3.13554

Keywords:

Chornobyl accident, histopathology, oncocytic cell changes, papillary thyroid carcinoma, post-operative follow-up

Abstract

Summary. Aim: To compare the frequency of main histopathological characteristics, 131І thyroid radiation doses, invasive properties and post-operative follow-up of patients of different age groups with potentially radiogenic papillary thyroid carcinoma (PTC) with the presence and absence of oncocytic changes in tumor cells. Materials and Methods: PTC removed in 483 patients from high risk age-group for radiogenic thyroid cancer development (children and adolescents at the time of Chornobyl accident who lived in the northern regions of Ukraine: Kyiv, Zhytomyr, and Chernihiv regions) have been studied microscopically. Results: The frequency of PTC with the presence of oncocytic changes (OCh) in tumor cells increased significantly with increasing of patients’ age at the time of surgery: from 8.3% in children 4–14 years old to 54.3% in adults 39–48 years old (ptrend < 0.0001). The presence of such changes is associated with papillary and solid-trabecular dominant tumor growth pattern in more than 90% of cases in each age group. The mean 131І thyroid dose in the whole series of PTC patients with OCh was significantly lower compared to the same index in PTC patients without OCh (493.7 mGy and 765.8 mGy, respectively, p < 0.0001). In addition, regional metastases recurrences were revealed more frequently in patients with OCh in primary PTC compared with patients without OCh in primary tumor (7.2% vs 1.5%, p = 0.0022). Conclusions: Significantly increasing age-trend of OCh in PTC of patients affected by the Chornobyl fallout and operated at age from 4 to 48 years, as well as opposite decreasing linear age-trend of 131І thyroid dose may reflect a gradual increase of sporadic PTCs frequency in the potentially radiogenic series with time elapsed since accident. The frequency of oncocytic insensitive to radioiodine therapy of lymph node metastases recurrences also increased with patients age and OCh availability in primary PTC.

References

Tronko M, Shpak V, Bogdanova T, et al. Epidemiology of thyroid cancer in Ukraine after Chernobyl. In: Tronko M, Bogdanova T, Saenko V, et al, eds. Thyroid canсer in Ukraine after Chernobyl: dosimetry, epidemiology, pathology, molecular biology. Nagasaki: IN-TEX, 2014: 39–64.

Tronko M, Bogdanova T, Shpak V, et al. Thyroid cancer in Ukraine during 1986–2014. In: Bazyka D, Sushko V, Chumak V, et al, eds. Health effects of Chornobyl accident. Thirty years aftermath. Kyiv: DIA, 2016: 85–103.

Bogdanova T, Saenko V, Shpak V, et al. Long-term Analysis of the Incidence and Histopathology of Thyroid Cancer in Ukraine in adult patients who were children and adolescents at the time of the Chernobyl accident. In: Yamashita S, Thomas G, eds. Thyroid cancer and Nuclear accidents — long term after effects of Chernobyl and Fukushima. Amsterdam: Elsevier, 2017: 67–76.

Brenner AV, Tronko MD, Hatch M, et al.I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident. Environ Health Perspect 2011; 19: 933–9.

Zablotska LV, Nadyrov EA, Rozhko AV, et al. Analysis of thyroid malignant pathologic findings identified during 3 rounds of screening (1997–2008) of a cohort of children and adolescents from Belarus exposed to radioiodines after the Chernobyl accident. Cancer 2014; 121: 457–66.

Tronko M, Brenner A, Bogdanova T, et al. Thyroid cancer risk in Ukraine following the Chernobyl accident (Ukrainian-American cohort thyroid study) accident. In: Yamashita S, Thomas G, eds. Thyroid cancer and Nuclear accidents — long term after effects of Chernobyl and Fukushima. Amsterdam: Elsevier, 2017: 77–86.

Tronko M, Brenner A, Bogdanova T, et al.Thyroid neoplasia risk is increased nearly 30 years after the Chernobyl accident. Int J Cancer 2017; 141: 1585–88.

Bogdanova T, Zurnadzhy L, LiVolsi VA, et al. Thyroid cancer pathology in Ukraine after Chernobyl. In: Tronko M, Bogdanova T, Saenko V, et al, eds. Thyroid canсer in Ukraine after Chernobyl: dosimetry, epidemiology, pathology, molecular biology. Nagasaki: IN-TEX, 2014: 65–108.

Bogdanova T, Saenko V, Zurnadzhy L, et al. Pathology of radiation-induced thyroid cancer: lessons from Chernobyl thyroid cancer study. In: Kakudo K, ed. Thyroid FNA cytology. Differential diagnoses and pitfalls. 2nd edition. Singapore: Springer, 2019: 549–64.

Bogdanova T, Saenko V, Zurnadzhy L, et al. Comparative pathological analysis of papillary thyroid carcinoma in age-matched groups of patients born before and after Chernobyl. In: Tronko M, Bogdanova T, Saenko V, et al, eds. Thyroid canсer in Ukraine after Chernobyl: dosimetry, epidemiology, pathology, molecular biology. Nagasaki: IN-TEX, 2014: 109–35.

Fridman M, Lam AK, Krasko O, et al. Morphological and clinical presentation of papillary thyroid carcinoma in children and adolescents of Belarus: The influence of radiation exposure and the source of irradiation. Exp Mol Pathol 2015; 98: 527–31.

Bogdanova TI, Saenko VA, Brenner AV, et al. Comparative histopathologic analysis of “radiogenic” and “sporadic” papillary thyroid carcinoma: patients born before and after the Chernobyl accident. Thyroid 2018; 28: 880–90.

Demidchik Yu, Fridman M, Schmid KW, et al. Papillary thyroid cancer in childhood and adolescence with specific consideration of patients after radiation exposure. In: Falety TJ, ed. Updates in the Understanding and Management of Thyroid Cancer. INTECH, 2012: 163–88.

Gross M, Eliashar R, Ben-Yaakov A, et al. Clinicopathologic features and outcome of the oncocytic variant of papillary thyroid carcinoma. Ann Otol Rhinol Laryngol 2009; 118: 374–81.

Abrosimov AY, Ryzhenkova MI. Morphological characteristic of papillary carcinoma recurrences. Arch Pathol 2014; 76: 13–9 (in Russian).

Tahmasebi FC, Farmer P, Powell SZ, et al.Brain metastases from papillary thyroid carcinomas. Virchows Arch 2013; 462: 473–80.

Djenic B, Duick D, Newell JO, et al. Solitary liver metastasis from follicular variant papillary thyroid carcinoma: A case report and literature review. Int J Surg 2015; 6: 146–9.

Woodford RL, Nikiforov YE, Hunt JL, et al.Encapsulated papillary oncocytic neoplasms of the thyroid: morphologic, immunohistochemical, and molecular analysis of 18 cases. Am J Surg Pathol 2010; 34: 1582–90.

Lloyd RV, Buehler D, Khanafshar E. Papillary thyroid carcinoma variants. Head Neck Pathol 2011; 5: 51–6.

Likhtarov I, Thomas G, Kovgan L, et al. Reconstruction of individual thyroid doses to the Ukrainian subjects enrolled in the Chernobyl Tissue Bank. Radiat Prot Dosimetry 2013; 156: 407–23.

Likhtarov I, Kovgan L, Masiuk S, et al. Different level of thyroid dose individualization of the Ukrainian donors in Chernobyl tissue bank. In: M Tronko, T Bogdanova, V Saenko, et al, eds. Thyroid canсer in Ukraine after Chernobyl: dosimetry, epidemiology, pathology, molecular biology. Nagasaki: IN-TEX, 2014: 19–38.

Thomas GA Bogdanova T, Tronko M, et al. Ukrainian contribution to the international Chernobyl Tissue Bank. In: M Tronko, T Bogdanova, V Saenko, et al., eds. Thyroid canсer in Ukraine after Chernobyl: dosimetry, epidemiology, pathology, molecular biology. Nagasaki: IN-TEX, 2014: 135–42.

WHO classification of tumours of endocrine organs: 4th edition. Lloyd RV, Osamura RY, Kloppel G, et al, eds. Lyon: IARC, 2017. 355 р.

Tronko MD, Bogdanova TI, Komissarenko IV, et al. Thyroid carcinoma in children and adolescents in Ukraine after the Chernobyl nuclear accident: statistical data and clinicomorphologic characteristics. Cancer 1999; 86: 149–56.

Williams ED, Abrosimov A, Bogdanova T, et al. Thyroid carcinoma after Chernobyl latent period, morphology and aggressiveness. Br J Cancer 2004; 90: 2219–24.

Thomas GA, Williams ED, Becker DV, et al. Chernobyl tumor bank. Thyroid 2000; 10: 1126–7.

Sobin LH, Gospodarowich MK, Wittekind C. TNM classification of Malignant Tumours (7th edition). Oxford: Wiley-Blackwell, 2009. 310 р.

TNM classification of Malignant Tumours: 8th edition. Brierley JD, Gospodarowich MK, Wittekind C, eds. Oxford: Wiley-Blackwell, 2017. 233 р.

Ito M, Bogdanova T, Zurnadzhy L, et al. Morphological difference in adult thyroid papillary carcinoma between Japan and Ukraine. Endocr J 2014; 61: 1221–8.

Hong JH, Yi HS, Yi S, et al. Implications of oncocytic change in papillary thyroid cancer. Clin Endocrinol (Oxf) 2016; 85: 797–804.

Nikiforov Y, Biddinger PW, Nikiforova MN, et al. Diagnostic pathology and molecular genetics of the thyroid (2nd ed). Philadelphia: Wolters Kluwer Health/Lippincott Williams and Wilkins, 2012. 375 p.

Downloads

Published

04.06.2023

How to Cite

Bogdanova, T., Zurnadzhy, L., Masiuk, S., Burko, S., Degtyaryova, T., Kovalenko, A., … Tronko, M. (2023). Histopathological characteristics and post-operative follow-up of patients with potentially radiogenic papillary thyroid carcinoma depending on oncocytic changes availability in the tumor cells. Experimental Oncology, 41(3), 235–241. https://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-3.13554

Issue

Vol. 41 No. 3 (2019): Experimental Oncology

Section

Original contributions

License

Copyright (c) 2023 Experimental Oncology

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.