Investigation of dosimetric impact of organ motion in static and dynamic conditions for three stereotactic ablative body radiotherapy techniques: 3D conformal radiotherapy, intensity modulated radiation therapy, and volumetric modulated arc therapy by usi
DOI:
https://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-2.13164Keywords:
3D conformal radiotherapy (3D CRT), intensity-modulated radiation therapy (IMRT), PRESAGE 3D dosimeter, stereotactic ablative body radiotherapy (SABR), volumetric modulated arc therapy (VMAT)Abstract
Summary. Aim: To investigate the use of PRESAGE 3D dosimeters to quantify the dosimetric variation between the static and dynamic conditions of three stereotactic ablative body radiotherapy techniques. Materials and Methods: An in-house custom-designed thorax dynamic phantom was designed to simulate the tumor motion in two directions (i.e., superior/inferior (Z-axis) and anterior/posterior (Y-axis)). The PRESAGE dosimeter was attached to the moving arm of the phantom and irradiated in two scenarios (static and dynamic) using three stereotactic ablative body radiotherapy (SABR) techniques: 3D conformal radiotherapy (3D CRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). Results: The highest differences in the mean volume measurements between the two conditions were noticed in IMRT (0.14 cm3) and 3D CRT (0.13 cm3). The mean volume measurements of the VMAT showed the lowest difference between the static and dynamic conditions of 0.10 cm3. The gamma analysis for 3%, 3-mm criterion showed passing rates of < 1 for 3D CRT, IMRT, and VMAT. Conclusion: This study quantify the dosimetric variations which are caused by the tumor motion in lung cases. In the SABR of the lung for QA purposes, this could help in identifying the prescription dose coverage due to tumor movement and correlate with the planned dose using 3D dosimeters like PRESAGE.
References
Zimmermann FB, Geinitz H, Schill S, et al. Stereotactic hypofractionated radiotherapy in stage I (T1-2 N0 M0) non-small-cell lung cancer (NSCLC). Acta Oncol 2006; 45: 796–801.
McGarry RC, Papiez L, Williams M, et al. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: phase I study. Int J Radiat Oncol Biol Phys 2005; 63: 1010–5.
van der Voort van Zyp NC, Prévost JB, Hoogeman MS, et al. Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: clinical outcome. Radiother Oncol 2009; 91: 296–300.
Huang L, Park K, Boike T, et al. A study on the dosimetric accuracy of treatment planning for stereotactic body radiation therapy of lung cancer using average and maximum intensity projection images. Radiother Oncol 2010; 96: 48–54.
Bissonnette JP, Franks KN, Purdie TG, et al. Quantifying interfraction and intrafraction tumor motion in lung stereotactic body radiotherapy using respiration-correlated cone beam computed tomography. Int J Radiat Oncol Biol Phys 2009; 75: 688–95.
Berbeco RI, Neicu T, Rietzel E, et al. A technique for respiratory-gated radiotherapy treatment verification with an EPID in cine mode. Phys Med Biol 2005; 50: 3669–79.
Keall P, Vedam S, George R, et al. The clinical implementation of respiratory-gated intensity-modulated radiotherapy. Med Dosim 2006; 31: 152–62.
Brady SL, Brown WE, Clift CG, et al. Investigation into the feasibility of using PRESAGE/optical-CT dosimetry for the verification of gating treatments. Phys Med Biol 2010; 55: 2187–201.
Guo PY, Adamovics JA, Oldham M. Characterization of a new radiochromic three-dimensional dosimeter. Med Phys 2006; 33: 1338–45.
Thomas A, Yan H, Oldham M, et al. The effect of motion on IMRT — looking at interplay with 3D measurements. J Phys Conf Ser 2013; 444: 012049.
Balagurusamy E. Programming in ANSI C. New Delhi: McGraw-Hill Education, 2002.
Chapman D, Heaton J. Teach yourself Visual C++ 6 in 21 days with Cdrom. Sams, 1998.
Radiology Support Devices. Basic Thorax. 2017 (http://www.rsdphantoms. com/pages/heartthoraxcardiac.html).
Gagliardi FM, Cornelius I, Blencowe A, et al. High resolution 3D imaging of synchrotron generated microbeams. Medical Physics 2015; 42: 6973–14.
Alqathami M, Blencowe A, Qiao G, et al. Optimizing the sensitivity and radiological properties of the PRESAGE® dosimeter using metal compounds. Radiat Phys Chem 2012; 81: 1688–95.
Annabell N, Yagi N, Umetani K, et al. Evaluating the peak-to-valley dose ratio of synchrotron microbeams using PRESAGE fluorescence. J Synchrotron Rad 2012; 19: 332–9.
Alqathami M, Blencowe A, Yeo UJ, et al. Novel multicompartment 3-dimensional radiochromic radiation dosimeters for nanoparticle-enhanced radiation therapy dosimetry. Int J Radiat Oncol Biol Phys 2012; 84: e549–55.
Alqathamia M, Blencoweb A, Qiao G, et al. Optimization of the sensitivity and stability of the PRESAGE™ dosimeter using trihalomethane radical initiators. Radiat Phys Chem 2012; 81: 867–73.
Kozicki M, Maras P. The polyGeVero® software for fast and easy computation of 3D radiotherapy dosimetry data. J Phys Conf Ser 2015; 573: 012070.
Kozicki M, Maras P, Karwowski AC. Software for 3D radiotherapy dosimetry. Validation. Phys Med Biol 2014; 59: 4111–36.
Butson MJ, Yu PK, Cheung T. Rounded end multi-leaf penumbral measurements with radiochromic film. Phys Med Biol 2003; 48: N247–52.
Clements N, Kron T, Franich R, et al. The effect of irregular breathing patterns on internal target volumes in four-dimensional CT and cone-beam CT images in the context of stereotactic lung radiotherapy. Med Phys 2013; 40: 021904.
Rietzel E, Liu AK, Doppke KP, et al. Design of 4D treatment planning target volumes. Int J Radiat Oncol Biol Phys 2006; 66: 287–95.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Experimental Oncology
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
