Aggregated proteins in malignant and benign neoplasms

Authors

  • D.I. Zabolotnyi Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine
  • A.A. Belousova Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine
  • D.D. Zabolotna Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine
  • T.D. Savchenko Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine
  • N.M. Voroshylova Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine
  • M.D. Timchenko Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine
  • I.R. Tsvirinko Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine
  • S.V. Verevka Institute of Otolaryngology named after Prof. A.I. Kolomiychenko of the National Academy of Medical Sciences of Ukraine

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-1.12629

Keywords:

benign neoplasms, keloids, malignant tumors, polyposis, protein aggregation

Abstract

Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology.

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Published

08.06.2023

How to Cite

Zabolotnyi, D., Belousova, A., Zabolotna, D., Savchenko, T., Voroshylova, N., Timchenko, M., … Verevka, S. (2023). Aggregated proteins in malignant and benign neoplasms. Experimental Oncology, 41(1), 61–68. https://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-1.12629

Issue

Vol. 41 No. 1 (2019): Experimental Oncology

Section

Hypothesis

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