LONG-TERM NATURAL HISTORY OF GIANT NULL CELL PITUITARY ADENOMA

Authors

  • O. UKRAINETS Department of Endonasal Skull Base Surgery, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • M. GUK Department of Endonasal Skull Base Surgery, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • O. DANEVYCH Department of Endonasal Skull Base Surgery, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • A. CHUKOV Department of Endonasal Skull Base Surgery, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • A. MUMLIEV Department of Endonasal Skull Base Surgery, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • M. SOLOVEY Department of Endonasal Skull Base Surgery, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • K. EGOROVA Department of Neuroophthalmology, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • D. TEVZADZE Department of Functional Neurosurgery, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
  • A. NABOICHENKO Subtentorial Neurooncology Department, State Institution “Romodanov Neurosurgery Institute, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine

DOI:

https://doi.org/10.15407/exp-oncology.2024.02.165

Keywords:

giant pituitary adenoma, null cell, third ventricle, endoscopic endonasal transsphenoidal surgery

Abstract

Pituitary adenomas that extend to the ventricular system are extremely rare. We present a 5-year natural history of a giant null cell pituitary adenoma with invasion into the cavernous sinus extending to the third ventricle. MRI series that were available could be useful for neurosurgeons, ophthalmologists, and endocrinologists as well as radiologists. Patients with the diagnosis of pituitary adenoma that are certain according to the radiological and clinical examination should be consulted by a neurosurgeon experienced in endoscopic endonasal surgery, a neuroendocrinologist, and an ophthalmologist. The surgery postponement in such cases results in disability and quality of life worsening. At that time, the surgery of giant pituitary adenomas demands high skills, and the risk of postoperative complications is high. The proper treatment modality including earlier surgery seems to be favorable for patient outcome.

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Published

09.10.2024

How to Cite

UKRAINETS, O., GUK, M., DANEVYCH, O., CHUKOV, A., MUMLIEV, A., SOLOVEY, M., … NABOICHENKO, A. (2024). LONG-TERM NATURAL HISTORY OF GIANT NULL CELL PITUITARY ADENOMA. Experimental Oncology, 46(2), 165–173. https://doi.org/10.15407/exp-oncology.2024.02.165