EVALUATION OF CURRENT FACTORS OF RADIATION-ASSOCIATED CARCINOGENESIS
DOI:
https://doi.org/10.15407/exp-oncology.2023.02.151Keywords:
radiation-induced carcinogenesis, irradiation, radiation therapy, ionizing radiationAbstract
The widespread introduction of nuclear technologies in industry, medicine, science, etc. increases the number of professionals subjected to additional radiation exposure. Moreover, the problem of occupational cancer is the most complicated in occupational pathology due to the multifactorial nature of the etiology of this disease. The radiation accidents in Chornobyl and Fukushima-1 showed that nuclear reactors cannot guarantee absolutely safe operation. At present, the threat of nuclear terrorism is increasing. Occupational radiation exposure and its consequences are also of great concern worldwide. Based on the literature data and our own studies on the effects of various types of radiation exposure, especially stochastic effects of radiation, it seems reasonable to develop a scientific basis for the optimization of radiation protection of various categories of population, first of all, medical personnel and patients. The complex assessment of radiation risks and reconstruction of the total ionizing radiation dose from all types of irradiation will allow optimizing radiation protection of the population and reducing carcinogenic risk..
References
Domina EA, Barilyak IR. Medical and genetic consequences of radiation catastrophes. Tsitol Genet. 2010;44(3):73- 81 (in Ukrainian).
Domina EA. Radiogenic Cancer: Epidemiology and Primary Prevention. Kyiv: Naukova Dumka, 2016. 196 p. (in Ukrainian).
Kundiev YuI, Nagornaya AM, Varivonchik DV. Professional Cancer: Epidemiology and Prevention. Kyiv: Naukova Dumka, 2008. 335 p. (in Russian).
Grinevich YuA, Domina EA. Immune and Cytogenetic Effects of Dense and Rare Ionizing Radiation. Kyiv: Avi- cenna, 2021. 384 p. (in Ukrainian).
Rajabi Pour M, Fardid R, Zare T, et al. Assessment of adaptive response of gamma radiation in the operating room personnel exposed to anesthetic gases by measuring the relative gene expression changes Ku80, Ligase1 and P53. J Biomed Phys Eng. 2020;10(2):225-234. doi: 10.31661/jbpe.v0i0.1273
Kogarko IN, Akleev AV, Petushkova VV, et al. Induction of adaptive response to chronic environmental and oc- cupational exposure to radiation. Radiation Risk. 2021;30:134-148. doi: 10.21870/0131-3878-2021-30-3-134-148
Communicating radiation risks in pediatric imaging: information to support health care discussions about benefit and risk. Geneva: WHO, 2016. 88 p.
Domina E. Evaluation of the impact of occupational exposure on cytogenetic parameters of peripheral blood lymphocytes. Dopovіdі NASU. 2018(10):112-119.
Cytogenetic dosimetry: Applications in preparedness for and response to radiation emergencies. Vienna: IAEA, 2011. 232 p.
Domina EA, Chekhun VF Experimental validation of prevention of the development of stochastic effects of low doses of ionizing radiation based on the analysis of human lymphocytes chromosome aberration. Exp Oncol. 2013; 35:65-68.
Domina E, Philchenkov A, Dubrovska A. Individual response to ionizing radiation and personalized radiother- apy. Crit Rev Oncog. 2018;23(1-2):69-92. doi: 10.1615/CritRevOncog.2018026308
Joiner MC, Kogel AJ. Basic Clinical Radiobiology. Fifth edition. Boca Raton, Florida: Pablishing CRC Press, 2018. 350 p.
Dörr W, Hendry JH. Consequential late effects in normal tissues. Radiother Oncol. 2001;61(3):223-231. doi: 10.1016/s0167-8140(01)00429-7
Kouvaris IR, Kouloulias VE, Vlanos V. Amifostin: the first selective – target and broad-spectrum radioprotector.
Oncologist. 2007;12(6):738-747. doi: 10.1634/theoncologist.12-6-738
Domina EA, Kopylenko OL. Role of radioprotectors in minimizing the occurrence of stochastic effects during radiation incidents. Exp Oncol. 2022;44(3):186-189. doi: 10.32471/exp-oncology.2312-8852.vol-44-no-3.18530
Domina EA. Anti-radiation means: classification and mechanisms. Probl Radiac Med Radiobiol 2015; 20:42-54.
Pavlenko TA, Operchuk AP. Cancer incidence of uranium mine personnel as a marker of the effectiveness of the radiation protection system at enterprises. Nuclear Radiation Safety, 2017; 3(75):56-59 (in Ukrainian).
Trimarche M, Harrison J, Laurier D, et al. Risk of lung cancer from radon exposure: contribution of recently published studies of uranium miners. Ann ICRP. 2012;41(3-4):368-377. doi: 10.1016/j.icrp.2012.06.033
Thomas DC, McNeill KG, Dougherty C. Estimates of lifetime lung cancer risks resulting from Rn progeny expo- sure. Health Phys. 1985;49(5):825-846. doi: 10.1097/00004032-198511000-00014
Ghiassi-Nejad M, Beitollahi MM, Asefi M, Reza-Nejad F. Exposure to (226)Ra from consumption of vegetables in the high level natural radiation area of Ramsar-Iran. J Environ Radioact. 2003;66(3):215-225. doi: 10.1016/ S0265-931X(02)00108-X
Hunter N, Muirhead CR, Bochicchio F, Haylock RG. Calculation of literature lung cancer risks associated with radon exposure, based on various models and exposure scenarios. J Radiol Prot. 2015;35(3):539-555. doi: 10.1088/0952-4746/35/3/539
Handbook on Indoor Radon: A Public Health Perspective. World Health Organization (WHO). WHO Press, Ge- neva, 2009.
Morgan WF. Is there a common mechanism underlying genomic instability, bystander effects and other nontar- geted effects of exposure to ionizing radiation? Oncogene. 2003;22(45):7094-7099. doi: 10.1038/sj.onc.1206992
Kovalchuk I, Kovalchuk O. Genome Stability: From Virus to Human Application. Academic Press. 2016. 712 p.
Domina E. Chornobyl Accident: Early and LongTerm Medical and Biological Effects. Saarbrucken: LAP LAM- BERT Academic Publishing, 2016. 106 p.
Kindzelsky LP, Zverkova AS, Sivkovich SA, Domina EA. Acute Radiation Sickness in the Conditions of the Chor nobyl Disaster. Кyiv: Teleoptik, 2002. 224 p.
Chekhun VF, Domina EA. Can SARS-CoV-2 change individual radiation sensitivity of the patients recovered from COVID-19? (experimental and theoretical background). Exp Oncol. 2021;43(3):277-280. doi: 10.32471/ exp-oncology.2312-8852.vol-43-no-3.16554
Pilinska MA, Dybsky SS, Dybska OB, et al. Peculiarities of induction and persistence of hidden chromosome instability in peripheral blood lymphocytes of persons occupationally exposed to ionizing radiation. Probl Radiat Med Radiobiol. 2014;19:321-333.
Submitted: June 1, 2023
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