NEW DATA ON HISTOGENESIS AND HISTOLOGICAL STRUCTURE OF LUNG CANCER
DOI:
https://doi.org/10.15407/exp-oncology.2023.01.062Keywords:
growth in the alveoli, histogenesis, histological research, immunohistochemical examination, lung cancerAbstract
Background: Lung cancer (LC) is one of the most common malignant neoplasms in men around the world, which poses a number of important challenges for scientists. Aim: To analyze the histogenesis, features of the histological structure, and growth of LC. Materials and Methods. The surgical material of 81 patients with LC was studied. Histological preparations were stained with hematoxylin and eosin (H&E) using the Papanicolaou method. Immunohistochemical reactions with monoclonals (Ki67, PCNA) were conducted. Results: In histological preparations of all LC types (squamous, adenocarcinoma, and small cell), along with solid growth, tumor growth in the alveoli was determined, which started from the basal membrane and grew toward the alveolus center, as evidenced by the morphological features of growth, tumor spread, and development of necrosis in the center. Conclusion: In all the studied histological preparations of LC, tumor growth in the alveoli is noted, which is confirmed by structural and cellular signs and the nature of tumor decay in the alveolus center, which corresponds to the general patterns of development of malignant epithelial tumors.
References
Sung H, Ferlay J, Siegel R. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71: 209–249. doi: 10.3322/caac.21660
Pennycuick A, Janes SM. On the origin of lung cancer. Am J Respirat Crit Care Med 2020; 201: 646–647. doi: 10.1164/recm.201911-2176ED
Fedorenko Z, Michailovich Yu, Goulak L, et al. Cancer in Ukraine: 2018–2019: incidence, mortality, rates of activity of oncological service. Bull Nat Cancer Reg Ukraine. National Cancer Institute of Ukraine 2020; 21: 46–47.
Verovkina V. Recent advances in immunotherapy in the treatment of cancer patients: the use of immunotherapy in non-small cell lung cancer. Clin Oncol 2018; 8: 228–231 (in Russian).
Semenova EA, Nage IR, Berns A, et al. Origins, genetic landscape, and emerging therapies of small cell lung cancer. Genes Dev 2015; 29: 1447–1462. doi: 10.1101/gad.263145.115
Grigoryeva E, Kokova D, Gratchev A. Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives. Exp Oncol 2015; 37: 5–12.
Sainz de Aja J, Dost AFM, Kim CF. Alveolar progenitor cells and the origin of lung cancer. J Intern Med 2020; 289: 629–635. doi: 10.1111/joim.13201
Bolgova L, Tuganova T. Lung Cancer: Issues of Histogenesis and Cytological Diagnosis: KIM, Kyiv, 2013. 168 p. (in Russian)
Travis WD, Brambilla E, Burke AP, et al. Thoracic tumours. WHO Classification of Tumours: Lyon, IARC Press, 2021. 572 p.
Weibel ER. Morphometry of Human Lungs: Medicine: Moscow, 1970. 174 p. (in Russian)
Zagorulko A, Askari T. Atlas of Ultrastructural Morphology of Respiratory Department: AZ-PRESS – SONAT, 2002. 142 p. (in Russian).
Bertoncello I. Stem Cells in the Lung. Development, Repair and Regeneration: Springer, 2015. 380 p.
Desai TJ. Development insights into lung cancer. Ann Rev Cancer Biol 2021; 5: 351–369. doi: 10.1146/annurev-cancerbio-070820-032858
Hogan BL, Barkauskas CE, Chapman HA, et al. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell 2014; 15: 123–138. doi: 10.1016/j.stem.2014.07.012.
Heng WS, Gosens R, Kruyt F. Lung cancer stem cells: origin, features, maintenance mechanisms and therapeutic targeting. Biochem Pharmacol 2019; 160: 121–133. doi: 10.1016/j.bcp.2018.12.010
Netter F. Atlas of Human Anatomy. Seventh ed.: Elsevier, 2019. 791 p.
Frank DB, Penkala IJ, Zepp JA, et al. Early lineage specification defines alveolar epithelial ontogeny in the murine lung. Proc Natl Acad Sci USA 2019; 116: 4362–4371. doi: 10.1073/pnas.1813952116
Chen Q, Rehman J, Chan M, et al. Angiocrine sphingosine-1-phosphate activation of S1PR2-YAP signaling axis in alveolar type II cells is essential for repair. Cell Rep 2020; 31: 107828. doi: 10.1016/j.celrep.2020.107828
Giangreco A, Reynolds SD, Stripp BR. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol 2002; 161: 173–182. doi: 10.1016/S0002-9440(10)64169-7
Bolgova L, Tuganova T, Alekseenko O, et al. Histogenesis of central lung cancer: cytological investigation. Exp Oncol 2020; 4: 310–313. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-4.15232.
Chen Z, Fillmore CM, Hammerman PS, et al. Non-smal-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer 2014; 14: 535–546. doi: 10.1038/nrs3775
Navarro S, Driscoll B. Regeneration of the aging lung: A mini-review. Gerontol 2017; 63: 270–280. doi: 10.1159/00045108.
Travis WD, Brambilla E, Burke AP, et al. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. WHO Classification of Tumours: Lyon, IARC Press 2015. p. 39.
Ferone G, Lee MC, Sage J, et al. Cells of origin of lung cancerogenesis. Genes Dev 2020; 34: 1017–1032. doi: 10.1101/gad.338228.120
Bolgova L, Tuganova T, Alekseenko O, et al. On the origin of lung cancer development. Exp Oncol 2022; 44: 17–22. doi: 10.3247/exp.oncology.2312-8852
Sousaa VML, Carvalho L. Heterogeneity in lung cancer. Pathobiol 2018; 85: 96–107. doi: 10.1159/000487440
Demura S, Kogan E, Goryachkina V. Chronic diseases, precancer, and cancer of lung, which are associated which pathology of the club cells of respiratory and terminal bronchioles. Arch Patol 2018; 80: 63–68. doi: 10.17116/patol20188005163
Kogan E, Kichigina O, Demura S. Morphological, immunohistochemical and radiological manifestation of lung tissue remodeling at lung sarcoidosis. Arch Patol 2012; 74: 37–43.
Beers M, Moodley Y. When is an alveolar type 2 cell an alveolar type cell? A conundrum for lung stem cell biology and regenerative medicine. Am J Respir Cell Mol Biol 2017; 57: 18–27. doi: 10.1165/rcmb.2016-0426PS
Gazdar A, Franklin WA, Brambilla E, et al. Pathology and genetics of Tumours of the Lung, Pleura, Thymus and Heart. Genetic and molecular alterations. World Health Organization Classification of Tumours: IARC Pres, 2004. p. 21.
Salahudden AA, Choi SS, Rustagi A, et al. Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature 2020; 588: 670–675. doi: 10.1038/s41586-020-3014-1
Bolgova L, Alekseenko O, Tuganova T, et al. Cytology, cytogenetic and ultrastructure investigation of the histogenesis of lung adenocarcinoma. Oncologiya 2008; 10: 334–338 (in Russian).
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