NEW DATA ON HISTOGENESIS AND HISTOLOGICAL STRUCTURE OF LUNG CANCER

Authors

  • L. Bolgova National Cancer Institute of the Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • A. Shypko National Cancer Institute of the Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • T. Tuganova National Cancer Institute of the Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • O. Alekseenko National Cancer Institute of the Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • I. Smolanka National Cancer Institute of the Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • A. Ponomarenko National University of Kyiv Mohyla Academy
  • N. Bilko National University of Kyiv Mohyla Academy

DOI:

https://doi.org/10.15407/exp-oncology.2023.01.062

Keywords:

growth in the alveoli, histogenesis, histological research, immunohistochemical examination, lung cancer

Abstract

Background: Lung cancer (LC) is one of the most common malignant neoplasms in men around the world, which poses a number of important challenges for scientists. Aim: To analyze the histogenesis, features of the histological structure, and growth of LC. Materials and Methods. The surgical material of 81 patients with LC was studied. Histological preparations were stained with hematoxylin and eosin (H&E) using the Papanicolaou method. Immunohistochemical reactions with monoclonals (Ki67, PCNA) were conducted. Results: In histological preparations of all LC types (squamous, adenocarcinoma, and small cell), along with solid growth, tumor growth in the alveoli was determined, which started from the basal membrane and grew toward the alveolus center, as evidenced by the morphological features of growth, tumor spread, and development of necrosis in the center. Conclusion: In all the studied histological preparations of LC, tumor growth in the alveoli is noted, which is confirmed by structural and cellular signs and the nature of tumor decay in the alveolus center, which corresponds to the general patterns of development of malignant epithelial tumors.

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Published

26.06.2023

How to Cite

Bolgova, L., Shypko, A., Tuganova, T., Alekseenko, O., Smolanka, I., Ponomarenko, A., & Bilko, N. (2023). NEW DATA ON HISTOGENESIS AND HISTOLOGICAL STRUCTURE OF LUNG CANCER. Experimental Oncology, 45(1), 62–69. https://doi.org/10.15407/exp-oncology.2023.01.062

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