EXPRESSION OF PROGRAMMED CELL DEATH RECEPTOR IN ENDOMETRIAL CANCER PATIENTS WITH METABOLIC DISORDERS

Authors

  • O.V. Kuzmenko Grigoriev Institute for Medical Radiology and Oncology, NAMS of Ukraine, Kharkiv 61024, Ukraine
  • P.P. Sorochan Grigoriev Institute for Medical Radiology and Oncology, NAMS of Ukraine, Kharkiv 61024, Ukraine
  • I.S. Gromakova Grigoriev Institute for Medical Radiology and Oncology, NAMS of Ukraine, Kharkiv 61024, Ukraine
  • V.G. Shevtsov Grigoriev Institute for Medical Radiology and Oncology, NAMS of Ukraine, Kharkiv 61024, Ukraine
  • M.O. Ivanenko Grigoriev Institute for Medical Radiology and Oncology, NAMS of Ukraine, Kharkiv 61024, Ukraine
  • M.V. Polozova Grigoriev Institute for Medical Radiology and Oncology, NAMS of Ukraine, Kharkiv 61024, Ukraine

DOI:

https://doi.org/10.15407/exp-oncology.2023.01.044

Keywords:

endometrial cancer, metabolic disorders, population and subpopulation composition of lymphocytes, programmed cell death receptor

Abstract

Aim: To study the expression of the programmed cell death receptor (PD-1) and its ligand (PD-L1) by immunocompetent cells in endometrial cancer patients with metabolic disorders. Materials and Methods: Populations and subpopulations of lymphocytes were analyzed by flow cytometry. Antibodies against CD279 were used to detect PD-1 on the CD4+ and CD8+ T cells. Antibodies against CD14 and CD274 were used to detect PD-L1 on monocytes. Results: In patients with severe metabolic disorders, the expression of PD-1 on CD8+ and CD4+ lymphocytes and the expression of the corresponding PD-L1 on CD14+ cells before treatment and after radiation therapy were higher than in the control group. Conclusion: Theincreased expression of PD-1 and PD-L1 receptors by immunocompetent cells can be considered a new prognostic marker in endometrial cancer patients with morbid obesity.

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Published

26.06.2023

How to Cite

Kuzmenko, O., Sorochan, P., Gromakova, I., Shevtsov, V., Ivanenko, M., & Polozova, M. (2023). EXPRESSION OF PROGRAMMED CELL DEATH RECEPTOR IN ENDOMETRIAL CANCER PATIENTS WITH METABOLIC DISORDERS. Experimental Oncology, 45(1), 44–50. https://doi.org/10.15407/exp-oncology.2023.01.044

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Original contributions