ROLE OF RADIOPROTECTORS IN MINIMIZATION OF STOCHASTIC EFFECTS OF RADIATION INCIDENTS
DOI:
https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-3.18530Keywords:
chromosome aberrations, genome instability, radiation emergency, radiomitigators, stochastic effectsAbstract
The real threat of emergency situations in Ukraine dictates the need to take into account the experience of previous radiation accidents, during which a significant part of the population was exposed to low-dose radiation. In such a case clinical manifestations of irradiation were mostly absent, while the danger of stochastic (carcinogenic) effects remained. Therefore, at present, the strategy of radiation protection of the population should be aimed at revising and choosing effective and low-toxic anti-radiation means. The main criterion for the development of stochastic consequences of exposure is radiation-induced genome instability, which is a promoter of carcinogenesis. The use of radiomitigators, which are able to weaken the harmful effect of ionizing radiation on critical highly radiosensitive systems of the human body, is promising. Our research showed the radiomitigative effect of inosine in cultured human T-lymphocytes on the genetic level with the significant decrease in the frequency of gamma-induced chromosome aberrations. The results experimentally justified an expediency of use of radiomitigators in the conditions of an emergency situation to minimize the occurrence and development of stochastic effects in population.
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