Expression pattern of MRPS18 family genes in gliomas
DOI:
https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16461Keywords:
bioinformatic analysis, expression pattern, glioblastoma, glioma cell lines, MRPS18 family, MRPS18-1, MRPS18-2, MRPS18-3Abstract
Summary. Aim: To assess expression patterns of MRPS18 family genes in glioblastoma tissues and glioma cell lines. Materials and Methods: Expression of MRPS18 family genes was analyzed by quantitative polymerase chain reaction in glioma cell lines and glioblastoma specimens. A bioinformatic analysis of the publicly available data on the expression of these genes was also provided. Results: The genes of MRPS18 family show different expression patterns in glioblastomas and glioma cell lines. The highest levels of expression were found for MRPS18-2 at mRNA and protein levels in both glioblastomas and glioma cell lines; the lowest — for MRPS18-1 at mRNA level. Conclusions: The elevated levels of relative expression of the MRPS18-2 gene are characteristic for glioma tumor tissues and cell lines.
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