Expression pattern of MRPS18 family genes in gliomas

Authors

  • L.M. Kovalevska R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • T.A. Malysheva The State Institution Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine
  • S.S. Kalman R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • A.V. Rozumenko The State Institution Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine
  • L.V. Verbova The State Institution Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine
  • V.D. Rozumenko The State Institution Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine
  • E.V. Kashuba R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

DOI:

https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16461

Keywords:

bioinformatic analysis, expression pattern, glioblastoma, glioma cell lines, MRPS18 family, MRPS18-1, MRPS18-2, MRPS18-3

Abstract

Summary. Aim: To assess expression patterns of MRPS18 family genes in glioblastoma tissues and glioma cell lines. Materials and Methods: Expression of MRPS18 family genes was analyzed by quantitative polymerase chain reaction in glioma cell lines and glioblastoma specimens. A bioinformatic analysis of the publicly available data on the expression of these genes was also provided. Results: The genes of MRPS18 family show different expression patterns in glioblastomas and glioma cell lines. The highest levels of expression were found for MRPS18-2 at mRNA and protein levels in both glioblastomas and glioma cell lines; the lowest — for MRPS18-1 at mRNA level. Conclusions: The elevated levels of relative expression of the MRPS18-2 gene are characteristic for glioma tumor tissues and cell lines.

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Published

26.05.2023

How to Cite

Kovalevska, L., Malysheva, T., Kalman, S., Rozumenko, A., Verbova, L., Rozumenko, V., & Kashuba, E. (2023). Expression pattern of MRPS18 family genes in gliomas. Experimental Oncology, 43(3), 204–208. https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16461

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