Expression pattern of MRPS18 family genes in gliomas
DOI:
https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16461Keywords:
bioinformatic analysis, expression pattern, glioblastoma, glioma cell lines, MRPS18 family, MRPS18-1, MRPS18-2, MRPS18-3Abstract
Summary. Aim: To assess expression patterns of MRPS18 family genes in glioblastoma tissues and glioma cell lines. Materials and Methods: Expression of MRPS18 family genes was analyzed by quantitative polymerase chain reaction in glioma cell lines and glioblastoma specimens. A bioinformatic analysis of the publicly available data on the expression of these genes was also provided. Results: The genes of MRPS18 family show different expression patterns in glioblastomas and glioma cell lines. The highest levels of expression were found for MRPS18-2 at mRNA and protein levels in both glioblastomas and glioma cell lines; the lowest — for MRPS18-1 at mRNA level. Conclusions: The elevated levels of relative expression of the MRPS18-2 gene are characteristic for glioma tumor tissues and cell lines.
References
Mushtaq M, Ali RH, Kashuba V, et al. S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma. Oncotarget 2016; 7: 55649–62.
Mints M, Mushtaq M, Iurchenko N, et al. Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1. Oncotarget 2016; 7: 22150–8.
Buchynska LG, Iurchenko NP, Kashuba EV, et al. Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas. Exp Oncol 2018; 40: 303–8.
Mushtaq M, Jensen L, Davidsson S, et al. The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells. Sci Rep 2018; 8: 2268.
Buivydiene A, Liakina V, Valantinas J, et al. Expression levels of the uridine-cytidine kinase like-1 protein as a novel prognostic factor for hepatitis C virus-associated hepatocellular carcinomas. Acta Naturae 2017; 9: 108–14.
Kovalevska L, Kashuba E. Expression pattern of MRPS18 family genes in malignantly transformed B-cells. Exp Oncol 2020; 42: 295–9.
Sorensen KM, Meldgaard T, Melchjorsen CJ, et al. Upregulation of Mrps18a in breast cancer identified by selecting phage antibody libraries on breast tissue sections. BMC Cancer 2017; 17: 19.
Uhlen M, Fagerberg L, Hallstrom BM, et al. Proteomics. Tissue-based map of the human proteome. Science 2015; 347: 1260419.
Uhlen M, Zhang C, Lee S, et al. A pathology atlas of the human cancer transcriptome. Science 2017; 357: eaan2507. https://doi.org/10.1126/science.aan2507.
Thul PJ, Akesson L, Wiking M, et al. A subcellular map of the human proteome. Science 2017; 356: eaal3321. https://doi.org/10.1126/science.aal3321.
Sadik N, Cruz L, Gurtner A, et al. Extracellular RNAs: a new awareness of old perspectives. Methods Mol Biol 2018; 1740: 1–15.
Sun L, Hui AM, Su Q, et al. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 2006; 9: 287–300.
Shai R, Shi T, Kremen TJ, et al. Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 2003; 22: 4918–23.
Karcher S, Steiner HH, Ahmadi R, et al. Different angiogenic phenotypes in primary and secondary glioblastomas. Int J Cancer 2006; 118: 2182–9.
Torsvik A, Stieber D, Enger PO, et al. U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells. Cancer Med 2014; 3: 812–24.
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