Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302а and -377 in tumor tissue


  • Yu.V. Vitruk National Cancer Institute, Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • S.L. Semko National Cancer Institute, Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • O.A. Voylenko National Cancer Institute, Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • M.V. Pikul National Cancer Institute, Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • T.V. Borikun R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • T.V. Zadvornyi R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • T.M. Yalovenko R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
  • E.O. Stakhovsky National Cancer Institute, Ministry of Health of Ukraine, Kyiv 03022, Ukraine
  • O.V. Rossylna Clinic for Personalized Diagnostics and Therapy Design “Oncotheranostics”, Kyiv 03022, Ukraine




miRNA, renal cell carcinoma, targeted therapy


Background: Renal cell carcinoma (RCC) is one of the most common solid tumors in adults highly resistant to conventional therapies. The expression profile of a number of miRNAs correlates with RCC response to chemotherapeutic agents. Aim: To identify the association of tumor miRNAs expression with neoadjuvant treatment response in patients with RCC. Materials and Methods: We analyzed the expression levels of tumor miR-99b, -144, -155, -210, -222, -302а, -377 in 93 RCC patients who received pazopanib or sunitinib in neoadjuvant regimen using RT-PCR. RNU48 was used as a reference miRNA. Results: The levels of expression of miR-99b and -377 are associated with the RCC response to pazopanib, and microRNA-210 and -377 to sunitinib. The characteristic expression profile of miR-99b, -144, -222, -377, and miR-302a determined in 90% of cases was delineated in pazopanib responders as opposed to nonresponders. Similarly, the characteristic expression profile of miR-210, -222, -302a and -377 was suggested for sunitinib responders. Conclusions: Levels of miR-99b, -210 and -377 expression in RCC tumor tissue might be used as a basis for future predictive panel intended for the assessment of the sensitivity to the regimens of neoadjuvant RCC treatment.


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How to Cite

Vitruk, Y., Semko, S., Voylenko, O., Pikul, M., Borikun, T., Zadvornyi, T., … Rossylna, O. (2023). Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302а and -377 in tumor tissue. Experimental Oncology, 43(2), 98–103. https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-2.16383



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