An uncommon case of vulvar cancer metastatic to breast
DOI:
https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-1.15843Keywords:
breast cancer, local neoplasm recurrence, metastasis, squamous cell carcinoma, vulvar neoplasmsAbstract
Summary. Vulvar carcinoma corresponds to the fourth gynecological malignancy in incidence, with more than forty thousand new cases being estimated worldwide in 2020. It is a disease characterized by locoregional spread presenting high recurrence rates although distant metastases are an uncommon event. The purpose of this work is to describe the diagnosis, treatment, and clinical course of vulvar carcinoma in a patient who presented regional recurrences and late metastasis to the mammary gland. Vulvar cancer is a disease with a well-defined natural history; but with the advancement of therapeutic possibilities in recent years, it has been possible to improve the prognosis, reducing the chance of locoregional recurrence. Thus, the possibility of distance recurrence must be remembered in inpatient follow-up with locally advanced vulvar carcinoma, even if atypically, as in the case reported.
References
Berek JS, Karam A. Vulvar cancer: epidemiology, diagnosis, histopathology, and treatment of rare histologies. UpToDate (15 May 2020). Available at: https://www.uptodate.com/contents/vulvar-cancer-epidemiology-diagnosis-histopathology-and-treatment-of-rare-histologies. Accessed: 20 May 2020.
Mancini S, Bucchi L, Baldacchini F, et al. Incidence trends of vulvar squamous cell carcinoma in Italy from 1990 to 2015. Gynecol Oncol 2020; 157: 656–63.
Weinberg D, Gomez-Martinez RA. Vulvar cancer. Obstet Gynecol Clin North Am 2019; 46: 125–35.
Wakeham K, Kavanagh K, Cuschieri K, et al. HPV status and favorable outcome in vulvar squamous cancer. Int J Cancer 2017; 140: 1134–46.
Hacker NF, Barlow EL. Staging for vulvar cancer. Best Pract Res Clin Obstet Gynaecol 2015; 29: 802–11.
Singareddy R, Bajwa HK, Alluri KR, et al. Carcinoma vulva patterns of recurrence and treatment outcomes: A single-institution experience. J Cancer Res Ther 2019; 15: 1328–31.
Vicus D, Korach J, Friedman E, et al. Vulvar cancer metastatic to the breast. Gynecol Oncol 2006; 103: 1144–6.
Verfaillie G, Garbar C, Vanhoeij M, et al. Metastasis of vulvar cancer in the breast. Acta Chir Belg 2012; 112: 444–6.
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424.
Kang YJ, Smith M, Barlow E, et al. Vulvar cancer in high-income countries: Increasing burden of disease. Int J Cancer 2017; 141: 2174–86.
Covens A, Vella ET, Kennedy EB, et al. Sentinel lymph node biopsy in vulvar cancer: a systematic review, meta-analysis and guideline recommendations. Gynecol Oncol 2015; 137: 351–61.
Oonk MH, Planchamp F, Baldwin P, et al. European Society of Gynaecological Oncology Guidelines for the management of patients with vulvar cancer. Int J Gynecol Cancer 2017; 27: 832–7.
Mahner S, Jueckstock J, Hilpert F, et al. Adjuvant therapy in lymph node–positive vulvar cancer: the AGO-CaRE-1 study. J Natl Cancer Inst 2015; 107: 1–12.
Te Grootenhuis NC, Pouwer AFW, De Bock GH, et al. Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review. Gynecol Oncol 2018; 148: 622–31.
Mota E, Mesquita IP, Pires C, et al. Hypercalcemia and extensive chest metastasis of vulvar squamous cell carcinoma. Eur J Case Rep Intern Med 2019; 6: 001218.
Bizzarri N, Vellone VG, Parodi L, et al. Cutaneous metastasis from vulvar squamous cell carcinoma: a rare occurrence that should not be forgotten. J Obstet Gynaecol 2017; 37: 975–81.
Seward SM, Richardson DL, Leon ME, et al. Metastatic squamous cell carcinoma of the vulva to the lung confirmed with allelotyping. Int J Gynecol Pathol 2009; 28: 497–501.
Schumacher A, Rohde E. Rare metastasis of vulvar cancers. Zentralbl Gynakol 1992; 114: 379–81.
Moreno-Astudillo L, Villaseñor-Navarro Y, Sánchez-Goytia V, et al. A case series of breast metastases from different extramammary malignancies and their literature review. Case Rep Radiol 2019: 2019: 9454201.
Khouchani M, Benchakroun N, Tahri A, et al. Breast metastasis from vulvar carcinoma: Case report and review of literature. Cancer Radiother 2008; 12: 120–5.
Bitencourt AG, Gama RR, Graziano L, et al. Breast metastases from extramammary malignancies: multimodality imaging aspects. Br J Radiol 2017; 90: 20170197.
Honda M, Saji S, Horiguchi S, et al. Clinicopathological analysis of ten patients with metaplastic squamous cell carcinoma of the breast. Surg Today 2011; 41: 328–32.
Parthasarathy A, Cheung MK, Osann K, et al. The benefit of adjuvant radiation therapy in single-node-positive squamous cell vulvar carcinoma. Gynecol Oncol 2006; 103: 1095–9.
Landrum LM, Lanneau GS, Skaggs VJ, et al. Gynecologic Oncology Group risk groups for vulvar carcinoma: improvement in survival in the modern era. Gynecol Oncol 2007; 106: 521–5.
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