Human microbiota and effectiveness of cancer chemotherapy


  • Yu.V. Shvets NSC “Institute of Biology and Medicine” of Taras Shevchenko National University of Kyiv, Kyiv 01033,Ukraine
  • N.Yu. Lukianova R.E. Kavetsky Institute of Experimental Pathology
  • V.F. Chekhun R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology



cancer, chemotherapy, microbiota, tumor-microbiota relationships


Summary. This review presents up-to-date information on the effects of microbiota on the individual chemotherapy sensitivity in cancer treatment. Recent studies have shown that a fine balance between the intestinal microbiota and the immune system is crucial for maintaining an efficacy of cancer chemotherapy. A number of antitumor drugs have complex mechanisms of action involving not only direct effects but also the activity of the intestinal microbiota and the immune system. A unique combination of these factors contributes to the individual chemotherapy sensitivity.


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How to Cite

Shvets, Y., Lukianova, N., & Chekhun, V. (2023). Human microbiota and effectiveness of cancer chemotherapy. Experimental Oncology, 42(2), 82–93.

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