FoxP3 gene polymorphism is associated with breast cancer in Iranian patients

Authors

  • F. Arabpour Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas 7919693116, Iran
  • A. Shafizad Department of Radiation Oncology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas 7919693116, Iran
  • M. Rahimzadeh Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas 7919693116, Iran
  • M. Norouzian Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
  • N. Naderi Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas 7919693116, Iran

Keywords:

breast cancer, FOXP3, polymorphism, Treg cells

Abstract

Summary. Aim: Breast cancer (BC) is one of the leading causes of cancer death among women. Recent studies have characterized FoxP3 as a marker of regulatory T cells and an X-linked tumor suppressor gene, which is involved in the pathogenesis of BC. Therefore, we investigated the potential influence of three single-nucleotide polymorphisms (SNPs) of FoxP3 gene on the development of BC in Iranian women. Materials and Methods: The association between FoxP3 rs2232365, rs3761548 and rs4824747 polymorphisms and BC risk was assessed in 124 BC patients and 198 healthy controls using sequence-specific primers. Results: We identified significant difference of rs3761548 in both allele and genotype frequencies between cases and control groups. Our results showed that individuals carrying FoxP3 rs3761548 AA genotype had about 4.3-fold increased risk of BC compared with CC carriers. No significant association was found between rs3761548C>A polymorphism and clinical outcome parameters (age of onset, tumor size, lymph nodes metastasis, tumor stage, progesterone receptor status, estrogen receptor status, Ki-67 status, HER-2 status and duration of disease). Conclusion: This study has provided the first genetic data on the FoxP3 gene polymorphism in south of Iran and proposes the rs3761548 polymorphism of FoxP3 gene as a risk factor, but not a prognostic marker in the development of BC in Iranian population.

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Published

17.06.2023

How to Cite

Arabpour, F., Shafizad, A., Rahimzadeh, M., Norouzian, M., & Naderi, N. (2023). FoxP3 gene polymorphism is associated with breast cancer in Iranian patients. Experimental Oncology, 40(4), 309–314. Retrieved from https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-8

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Original contributions