ANTICANCER AND IMMUNOSTIMULATORY EFFECTS OF NUCLEOPROTEIN FRACTION OF BACILLUS SUBTILIS 7025 CULTURE MEDIUM FILTRATE

Shlyakhovenko V.O.*, Olishevsky S.V., Kozak V.V., Yanish Yu.V., Rybalko S.L.

• V.L. Gromashevsky Research Institute of Epidemiology and Infectious Diseases, Medical Academy of Sciences of Ukraine, Kyiv, Ukraine

Summary. Antitumor and immunostimulatory effects of nucleoprotein fraction of Bacillus subtilis 7025 (NPF) cultural medium filtrate have been investigated. Although a number of important questions remains to be answered our experiments indicated that NPF of Bacillus subtilis 7025 cultural medium filtrate can be effective as antitumor immunotherapeutic agent, has significant immunostimulatory effects and augments NK cell cytotoxicity and IFN-a/g-producing activity of leukocytes.