STAGE OF DIFFERENTIATION, PROLIFERATIVE INDEX OF TUMOR CELLS AND CYTOTOXIC ACTIVITY OF PERIPHERAL BLOOD LYMPHOCYTES IN COLORECTAL CANCER PATIENTS
Aim: To evaluate prognostic value of activity of cytotoxic lymphocytes of peripheral blood (CTL) of patients with colorectal cancer (CRC). Methods: 2-year survival of 30 patients with colorectal cancer stage II (T2–3N0–1M0G1–3) was investigated in relation with clinical data, cytotoxic activity of peripheral blood lymphoсytes (by МТТ-test) and immunohistochemical peculiarities of tumor cells using anti-Ki-67-MABs. Results: It was revealed that some factors had prognostic significance, namely regional lymph nodes involvement (r = –0.69), proliferative activity of tumor cells (Ki-67-positivity) (r = –0.67), restoration of CTL function after operation (r = 0.46), adjuvant chemotherapy (r = 0.41) and differentiation stage of tumor (r = 0.40). Negative correlation between CTL activity before operation and tumor proliferative activity also exists (r = –0.35). Conclusion: the data point to the involvement of natural killer cells in the control of tumor growth.
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