NOVEL CYTOGENETIC FINDINGS REVEALED BY CONVENTIONAL CYTOGENETIC AND FISH ANALYSES IN LEUKAEMIA PATIENTS

Karauzum S.B., Bilgen T., Karadogan I., Yakut S., Cetin Z., Ugur A., Luleci G.

Aim: To describe novel cytogenetic findings in four leukaemia patients. Methods: Conventional cytogenetic (CC) and fluorescence in situ hybridization (FISH) analyses were performed on bone marrow samples of four leukaemia patients. Results: In this study, t(3;10)(q11;q25) and t(2;22)(p21;q11.2) were detected as novel translocations. t(8;16;21)(q22.1;q13;q22) and t(1;6;9;22)(p36.1;p21.3;q34;q11) were found as variant translocations, and these variant translocations were confirmed by Interphase-FISH and Multicolour-FISH. Conclusion: Newly identified cytogenetic findings can lead us to characterize cytogenetic evolution of the haematological malignancies. Further investigations are certainly warranted to resolve the prognostic impact of these new cytogenetic abnormalities.