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NOVEL CYTOGENETIC FINDINGS REVEALED BY CONVENTIONAL CYTOGENETIC AND FISH ANALYSES IN LEUKAEMIA PATIENTSKarauzum S.B., Bilgen T., Karadogan I., Yakut S., Cetin Z., Ugur A., Luleci G. Aim: To describe novel cytogenetic findings in four leukaemia patients. Methods: Conventional cytogenetic (CC) and fluorescence in situ hybridization (FISH) analyses were performed on bone marrow samples of four leukaemia patients. Results: In this study, t(3;10)(q11;q25) and t(2;22)(p21;q11.2) were detected as novel translocations. t(8;16;21)(q22.1;q13;q22) and t(1;6;9;22)(p36.1;p21.3;q34;q11) were found as variant translocations, and these variant translocations were confirmed by Interphase-FISH and Multicolour-FISH. Conclusion: Newly identified cytogenetic findings can lead us to characterize cytogenetic evolution of the haematological malignancies. Further investigations are certainly warranted to resolve the prognostic impact of these new cytogenetic abnormalities. No Comments » Add comments |
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