EFFECT OF PHOTODYNAMIC THERAPY ON TUMOR ANGIOGENESIS AND METASTASIS IN MICE BEARING LEWIS LUNG CARCINOMA
Aim: To investigate the influence of photodynamic therapy (PDT) on the tumor angiogenesis and metastasis. Methods: The effect of PDT with a photosensitizer 5-aminolaevulinic acid (ALA) on tumor metastasis and angiogenesis was studied on the model of subcutaneously implanted Lewis lung carcinoma (3LL) in C57Вl/6 mice. VEGF level in blood serum of animals was evaluated by ELISA. Results: It has been shown that application of ALA-PDT resulted in the lowered rate of metastatic spreading and decreased VEGF level in blood serum of 3LL-bearing mice, and morphologic alterations of vascular system in tumor tissue. Conclusion: The antitumor action of PDT using ALA as a photosensitizer is caused partly by antimetastatic and photodamaging effect mediated by vascularization disturbances in tumor tissue.
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