Role of endometrial hyperplasia in prognosis of survival of patients with ovarian cancer

Tkalya J.G., Vorobjova L., Svintitsky V.S.

J.G. Tkalya, L.I. Vorobyova, V.S. Svintsitsky

National Cancer Institute, Kyiv, Ukraine

Introduction: In ovarian cancer (OC) patients endometrial pathology is diagnosed, that is explained by the common risk factors and pathogenesis of the diseases. The aim: To study the relationship between general and recurrence-free survival rate in OC patients and presence/absence of associated endometrial hyperplasia (EH). Patients and Methods: Retrospective analysis of history of diseases in 303 OC patients with stages I-IV who underwent standard treatment according to the radical program in National Cancer Institute within 2001–2008 years. The study protocol was approved by Ethical Committee permission of National Cancer Institute (Kyiv, Ukraine). Results: Group of OC patients with EH composed 59.1% (among those — reproductive age patients made up 46.9%, menopausal period patients — 53.1%), without EH — 40.9% (among those — reproductive age patients made up 30.5%, menopausal period patients — 69.5%). The morphology of ovarian tumor of patients with associated EH were allocated as follows: papillary adenocarcinoma — 69.8%, stromal tumors — 11.2%, mucinous cancer — 6.1%, germinogenic tumors — 3.3%, non-differentiated adenocarcinoma — 1.7%, endometrioid cancer — 1.1%. Correlation relationship of general and recurrence-free survival rates was defined in the investigated patients due to presence or absence of associated EH. It was shown that the median of recurrence-free survival of OC patients with EH made up 60 months, while in absence of EH — 24 months (< 0.05). The five-year survival rate in OC patients with EH composed 53%, in absence of EH — 32% (< 0.05). It is worth to note that early recurrences of the disease (prolongatio morbi) was observed in 24% of OC patients in presence of EH and in 76% patients with its absence (< 0.05). Conclusions: Thus, the presence of benign endometrial changes is a favorable prognostic sign that is associated with OC prognosis. The obtained data have practical significance as predictive factors for estimation of OC prognosis.

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