ACTIVATED N-RAS ONCOGENE INHIBITS THE EXPRESSION OF PDGF-BETA RECEPTOR IN MYOBLAST CELLS

Zeytinoglu H., Griffiths S.L., Gibson I.

By RT-PCR technique mRNA levels of platelet-derived growth factor type-beta receptor (PDGF-beta-R) and MyoD1 in a myoblast cell line carrying human N-ras oncogene have been investigated. After dexamethasone treatment an activation of N-ras and inhibition of the PDGF-beta-R and MyoD1 genes transcription was observed. Those results suggested that cells transformed with the N-ras oncogene fail to respond to PDGF-BB due to the absence of PDGF-beta-R mRNA.

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