DETECTION OF TUMOR RESPONSE TO Co(III) AND Fe(III) COMPLEXES BY 31P-NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Bubnovskaya L.N., Mikhailenko V.M., Kondrichin I.G., Osinsky S.P., Kovelskaya A.V., Sigan A.L., Levitin I.Ya.

A comparative analysis of the effects of several Co(III) and one Fe(III) complexes, as well as that of CoCl2 on the “bioenergetic status” as well as tumor hypoxia in Guerin carcinoma has been carried out using 31P NMR. Existence of the inverse correlation between the changes in the “bioenergetic status” of tumor tissue after complexes administration and their antitumor efficacy has been shown in experiments in vivo. The hypoxia levels in tumor that were registered under these conditions have been corresponded to antitumor activities of the complexes. Complexes were shown to exhibit a time-dependent influence on tissue energy metabolism. It has been also demonstrated that 31P NMR spectroscopy may be used to characterize the physiological state of tissues and applied on optimization of drug design and prediction of antitumor efficacy of newly synthesized substances.

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