PROCOAGULANT ACTIVITIES IN THE PLASMA OF A PATIENT WITH PERITONEAL METASTASIS FROM PANCREATIC NEUROENDOCRINE TUMOR: A CASE REPORT

Micco P. Di, Federico A., Lucia D. De, Sio I. de, Niglio A., Romano M.

We report a case of peritoneal metastasis from pancreatic neuroendocrine cancer occurring in a 58-year-old male. The disease showed a profound perturbation of haemostasis with a 15-fold increase in prothrombin activation fragment 1+2 (F₁₊₂), a marker of thrombin generation, combined with high levels of fibrinogen and d-dimer. This testifies the high thrombotic risk in patients with advanced pancreatic cancer of neuroendocrine origin and prophylactic use of low molecular weight heparin might be warranted in order to decrease the incidence of thrombotic events and thromboembolic complications in these patients.