EVALUATION OF EFFECTIVENESS OF ANTITUMOR VACCINES OBTAINED WITH THE USE OF METABOLIC PRODUCTS OF BACILLUS SUBTILIS AB-56

Potebnya G.P., Khutornoi S.V.

Antitumor activity of homologic vaccines prepared with the use of metabolic products of B. subtilis AB-56 were studied on sarcoma-37 model. The relation of tumor growth dynamics in mice that received vaccine injections with production of antibodies to homologic vaccine antigens was revealed. Those results may be used for production of antitumor vaccines on the base of glycoproteid isolated from culture fluid of B. subtilis AB-56 and tumor cells, their standartization and evaluation of their effectiveness.