APPLICATION OF TUMOR MARKER ANTIGENS ON IMMUNOTHERAPY OF PATIENTS WITH COLORECTAL CANCER

Lisovenko S.G., Potebnya G.P., Kolesnik E.A., Kikot V.V.

In the review, data of the up-to-date literature on use of well-studied tumor-associated antigens (17-1A, 791gp72 and CEA) in immunotherapy of patients with colorectal cancer (CRC) are presented. For stimulation of the immune system with these antigens, different approaches including immunization with peptides, antiidiotypic antibodies, DNA-vaccines, vaccines on the basis of viral vectors, have been developed. On the basis of the obtained data it is possible to assert that the immune response against CRC cells can be induced using the mentioned methods. The potential possibilities for application of tumor marker antigens on immunotherapy of CRC is limited due to expensive cost of such treatment and relatively low level of clinical efficacy.