MEMBRANE PROTECTIVE ACTION OF CERULOPLASMINE UPON THE USE OF DOXORUBICINE IN VIVO

Berdinskih N.K., Gogol S.V., Gunina L.M., Lyalyushko N.M.

The mechanism of membrane protective action of ceruloplasmine upon doxorubicine administration to intact animals at the dose of 7 mg/kg has been investigated. By inhibition of peroxidation processes, ceruloplasmine promotes normalization of quatitative and qualitative lipid content of plasma membranes of hepato- and cardiocytes, and significantly improves the functional state of erythrocyte membranes.