ANTIGEN-PRESENTING CELLS FROM SPLEEN OF TUMOR-BEARING MOUSE IN THE MIXED LEUKOCYTE REACTION

Sevko A.L., Smirnova I.A.

We have shown that functional activity and phenotype of spleen generated dendritic cells (DC) are dependent on the mode of lymphoma cell transplantation. Proliferation rate of the spleen antigen presenting cells (APC) was significantly increased in the case of subcutaneous and intraperitoneal lymphoma cells transplantation and close to the control value in the case of intravenous transplantation. In the last case the IAb expression on the surface of spleen APC was shown to be significantly lower in comparison with control group. The appearance of CD11c+ cells in the different organs at the 7th day after transplantation pointed to the transitional activation of DCs. In all groups of animals at the 14th day after tumor cell transplantation, the notable decrease of CD11c, but not NLDC-145+, level was detected.

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