Markeeva N.V.1, Lyzogubov Valeriy2, Usenko Vasilij3, Lisovskiy Igor4, Soldatkina Maria5, Merentsev Serhey6, Zaitsev Serhey7, Kondratskii Yuriy8, Tofan Anatoliy9, Osinskiy Serhey10

Summary. The present work was aimed on the study of patterns of human beta-defensin-2 (hBD-2) expression in human gastric tumors. Materials and methods: 17 samples of surgically resected human gastric adenocarcinoma paired with respective normal tissue controls have been analyzed for the expression of hBD-2 by semi-quantitative RT-PCR and by immunohistochemical analysis using anti-hBD-2 monoclonal antibodies (mAbs) generated against recombinant hBD-2 by standard hybridoma technology. Results: The hyperexpression of hBD-2 on mRNA and protein levels was registered in 6 from 17 gastric tumor samples compared to respective controls; however, hBD-2 expression patterns seems not be related to the differentiation grade and stage of tumors and the presence of anti-Helicobacter pylori-antibodies in the blood serum of the patients. Conclusion: In human gastric adenocarcinomas expression of hBDs possesses heterogeneic character; the research on larger cohort of the patients with gastric cancer should be further performed.

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