RESISTANCE OF GUERIN’S CARCINOMA CELLS TO CISPLATINE: BIOCHEMICAL AND MORPHOLOGICAL ASPECTS

Yurchenko O.V., Todor I.N., Tryndyak V.P., Tregubova N.A., Kovtonyuk O.V., Solyanik G.I., Kulik G.I., Chekhun V.F.

• Ukrainian Research Institute of Oncology and Radiology, Ministry of Health of Ukraine, Kyiv 03022, Ukraine

Summary. The present work is focused on the study of patterns of bioenergetics and morphology of Guerin’s carcinoma cells upon the development of cisplatine resistance. It is shown, that this process is accompanied by activation of oxidative phosphorylation and of glutathione detoxification systems as well as by complication of morphological organization of tumor cells pointing to the increased level of their differentiation.