Antitumor efficacy of autovaccines prepared from chemoresistant tumor cells with theuse of lectin of B. subtilis B-7025

Potebnya G., Cheremshenko N., Lisovenko G.1, Voyekova I., Bazas’ V., Todor I.N.1, Chekhun V.2

Summary. Aim: To study whether immunogenecity of tumor cells may be altered upon the development of cytostatic drug resistance and what is the efficacy of vaccines prepared from such tumor cells. Methods: Using immunological methods, the influence of vaccines prepared from Lewis lung carcinoma (LLC) cells, sensitive or resistant to cisplatin, with the use of cytotoxic lectins of B. subtilis В-7025 on the course of tumor development and the main effector reactions of antitumor resistance has been studied. Results: The vaccine prepared from the cells of chemoresistant LLC and lectines of B. subtilis B-7025 possesses antitumor activity, what is evidenced by the indexes of tumor growth inhibition and increased activity of effector cells of antitumor immunity. Conclusions: The antitumor action of vaccines prepared with the use of chemoresistant tumor cells is differing is more pronounced, than in the case of chemosensitive variant.

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