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EXPRESSION OF p53, p21WAF1/CIP1, p16INK4A AND Ki-67 PROTEINS IN SEROUS OVARIAN TUMORS
Aim: The analysis of p53, p21WAF1/CIP1, p16INK4a and Ki-67 expression in serous ovarian carcinomas of different grade. Materials and Methods: In total, 43 ovarian adenocarcinomas and 8 non-altered ovarian epithelial tissues were immunohistochemically investigated for expression of Кі-67, р53, р21WAF1/CIP1 and р16INK4a. Results: It has been shown that expression of Кі-67, р53, р21WAF1/CIP1 and р16INK4a in non-altered ovarian epithelial tissue is absent. Serous ovarian carcinomas are characterized by high proliferative activity (PI Кі-67 = 30.0 ± 0.3%), р53 and р16INK4a overexpression (LI is 40.3 ± 0.3% and 31.1 ± 0.6% respectively) and low expression of р21WAF1/CIP1 (LI = 6.8 ± 0.3%). The association between expression of these markers and ovarian tumor grade was defined: the maximal level of Кі-67, р53 and p16/INK4a and minimal of p21WAF1/CIP1 expression were observed in G3 tumors. So, low p21WAF1/CIP1 expression (LI < 7.0%) combined with р16INK4a overexpression is considered to be the factor for a poor prognosis in serous ovarian cancer. Conclusions: The present study has indicated that biomolecular markers of cell proliferation along with traditional clinical and morphologic characteristics can be used for differential diagnostics of ovarian tumors.
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