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MODERN TRENDS IN CANCER VACCINOTHERAPY
Summary. Modern data on cancer vaccines have been reviewed. The mechanism facilitating tumor cells to escape the immune surveillance have been considered with particular emphasis on the significance of tumor-associated (TAA) and tumor-specific (TSS) antigens, proteins of the major histocompatibility complex (MHC), adhesion molecules, and molecules enhancing immune response. The efforts on the elaboration of the recombinant vaccines as well as vaccines on the basis of nucleic acids and glycopeptides have been analyzed. The outlooks for new vectors designed for introducing genetic material into tumor cell genome as well as advantages of liposomes and substances enhancing immune responce have been outlined as well. Recent results and further prospects in the field of cancer vaccinotherapy have been analyzed.
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