HETEROGENEITY OF GLYCOPROTEIN FRACTIONS IN BLOOD SERUM OF TUMOR-BEARING ANIMALS

Surgova T.M., Sidorenko M.V., Galich I.P., Evtushenko N.V.

Glycoprotein fractions (GPF) from blood serum of tumor-bearing animals (B16 melanoma and Guеrin carcinoma) were purified by affinity chromatography on Sepharose columns and analyzed. The growth of transplantable tumors was shown to be accompanied by the changes in structure and properties of GPFs under study, in particular by the changes in sugar content in the carbohydrate moieties of GPFs. The content of fucose in serum decreased as far as the tumors were increasing in size.