EVALUATION OF ANTITUMOR EFFICACY OF ESTRAZIN IN RAT PROSTATIC ADENOCARCINOMA

Smirnova Z.S., Kulagina T.F., Osetrova I.P., Khrustalev S.A., Ustinov A.T., Gerasimova G.K.

Therapeutic effect of estrazin was evaluated on transplantable R3327-H Dunning rat prostatic adenocarcinoma. Delayed and prolonged antitumor action of estrazin has been demonstrated with maximum inhibition of tumor growth being attained two month after cessation of such a treatment. Inhibition of tumor growth at a dose of 100 mg/kg has amounted to 82%. Therapeutic effect of esrtazin exceeded that of both estracyt and flutamide.