REDOX STATE OF NICOTINAMIDE NUCLEOTIDES AND ANTIOXIDANT ENZYME ACTIVITIES IN C-27 HEPATOMA TISSUE AND LIVER OF TUMOR-BEARING RATS
The relationships between the redox state of nicotinamide nucleotides, lipid peroxidation, and antioxidant enzyme activities in both liver of tumor-bearing rats and C-27 hepatoma tissue have been studied. It was found that tumor tissue exhibited low content of oxidized forms of nicotinamide nucleotides (NAD+ and NADP+ ) and lowered ratio of free NAD+ /NADH and NADP+ /NADPH in cell cytosol as well as low lipid peroxidation level and inhibition of superoxide dismutase and catalase activities. Similar but less significant changes occurred in the liver of tumor-bearing rats. The increase in glutathione peroxidase and glutathione reductase activities in both liver of tumor-bearing rats and C-27 hepatoma tissue suggests that exactly these enzymes play a leading role in antioxidant defense system in tumor-bearing hosts.
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