CYTOGENETIC ALTERATIONS IN HEp-2 CELLS INFECTED WITH EPSTEIN—BARR VIRUS

Sevostyanova N.V., Rudakova E.G., Isaeva T.M., Plotnikova N.N., Urazova L.N.

The cytogenetic indices in HEp-2cell culture infected with Epstein—Barr virus have been studied. Proliferation index was demonstrated to increase in 24 and 48 h upon infection. Infected HEp-2 cells showed statistically significant increase in amounts of pathological mitoses, micronuclei, and chromosomal aberrations.