HISTOPATHOLOGIC DIAGNOSIS OF MALIGNANT LYMPHOMAS BASED ON CLASSIFICATION OF WORLD HEALTH ORGANIZATION
Summary. The principles of the diagnosis of malignant lymphomas in accordance with new WHO classification have been considered. The histopathologic criteria provide for 80–95% reproducibility in the diagnosis of the different lymphoma entities. Immunohistochemistry with a large panel of monoclonal antibodies to differentiate lymphomas of B-, Tand NK-cell origin should be done step by step when necessary. The criteria used to delineate lymphomas originating from lymphoid precursor cells and mature (peripheral) lymphocytes have been treated in details. Small B-cell lymphomas, B-CLL, mantle cell lymphoma, marginal zone lymphoma, follicular lymphoma, lymphoplasmacytic lymphoma, large B-cell lymphomas, Burkitt’s lymphoma, T-cell lymphoma, Hodgkin’s lymphoma have been characterized on the basis of their histomorphology and immunophenotyping.
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