ANTICANCER AND ANTIVIRAL PROPERTIES OF MACROCYCLIC PYRIDINOPHANES AND THEIR DERIVATIVES

Fedchuk A.S., Lozitsky V.P., Dyachenko N.S., Nosach L.N., Povnitsa O., Zhovnovataya V.L., Eynde J.J. Vanden, Lozitskaya R.N., Kamalov G.L., Kryzhanovsky D., Kuzmin V.E., Sausville E.

The permanent search for new anticancer and antiviral substances is a high-priority task. Macrocyclic pyridinophanes (MCPs) attract much attention as promising compounds with high potential of pharmaco-biological properties. The results of the experimental study of anticancer and antiviral properties of newly synthesized MCP, their analogues and derivatives have been presented. Several compounds under study have been shown to possess strong anticancer (against human cancer cell lines) and antiviral (inhibition of adenovirus type 5 and influenza virus A/Hong Kong/1/68 reproduction) activity in vitro. Several MCP studied were shown to share anticancer and antiviral properties. The results obtained in experiment will be used for molecular topological QSAR model evaluation.

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