INFLUENCE OF Pt-DNA-ІІІ ON THE SURVIVAL OF CULTURED CELLS OF HUMAN BRAIN TUMORS
The influence of different doses of the platinum derivative Pt-DNA-ІІІ on the survival of cultured cells obtained from brain tumors of 13 operated patients was investigated. The treatment of cell cultures for 24 h with Pt-DNA-ІІІ at the increasing doses from 7.5 to 30 мg/ml resulted in the monotonous decrease of the cell survival. At the highest dose of the drug the inhibition of cell reproduction (70–90%) was observed.
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