INFLUENCE OF VACCINATION WITH CANCER AUTOVACCINE ON SOME INDICES OF IMMUNE STATUS OF PATIENTS WITH RECTAL ADENOCARCINOMAS

Lisovenko G.S., Potebnia G.P., Semernikov V.A., Khutornoy S.V., Kolesnik E.A., Telezhinskaya E.V., Shlyakhovenko V.O.*

Summary. Some parameters of cellular and humoral immunity of the patients with adenocarcinomas of rectum were investigated upon anticancer autovaccine treatment. It was found that such an immunization resulted in normalization of the CD4⁺- and CD8⁺-lymphocyte count. Production of a-interferon increased considerably. A fraction of autovaccine, which reacts with Т cells and humoral antibodies, has been detected. CEA content after vaccination increased considerably comparatively to its level before operation.