ANTIGENOTOXIC ACTION OF “NARINE” LACTOBACILLI IN RAT COLON CELLS IN VITRO

Nersesyan A.K.

Possible antigenotoxic action of lactobacilli “Narine” (LB, Lactobacillus acidophilus, strain 317/402), widely used for milk fermentation for babies’ food in Armenia was studied in vitro using the single cell gel electrophoresis technique (the comet assay). Whole 24 h LB culture, supernatant of this culture and pellet, supplemented with fresh growth medium were incubated with rat colon cells and potent carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. The results have shown that only pellet of lactobacilli culture supplemented with fresh growth medium decreased significantly the length of DNA migration (DNA damage).